Clinicopathologic features of CDK6 translocation-associated B-cell lymphoproliferative disorders.

The American Journal of Surgical Pathology
Dong ChenA Dogan

Abstract

Cyclin-dependent protein kinase 6 (CDK6), in cooperation with cyclin Ds, drives cell cycle progression from G1 to S phase through phosphorylation and subsequent inactivation of retinoblastoma 1 protein. Alteration of this pathway results in both nonhematologic and hematologic malignancies, which include a small subset of B-cell lymphoproliferative disorders (BLPDs). We identified 5 cases of BLPD that carried CDK6 chromosomal translocations and characterized their clinical, pathologic, immunophenotypic, and genetic features. Common clinical characteristics included marked neoplastic lymphocytosis, systemic lymphadenopathy, splenomegaly, and bone marrow involvement. Three patients were diagnosed with low-grade B-cell lymphoma and had an indolent clinical course, and 2 patients (one who transformed to large B-cell lymphoma, and the other who was initially diagnosed with a high-grade B-cell lymphoma) had an aggressive clinical course. Immunophenotypically, the neoplastic B cells expressed CD5, CDK6, and cytoplasmic retinoblastoma 1 protein in all cases, expressed phospho-RB, p27kip1, and cyclin D2 in most cases, and uniformly lacked expression of all other cyclins. In 4 cases, the CDK6 translocation partner was kappa immunoglobulin...Continue Reading

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Citations

Jan 10, 2012·The Journal of Biological Chemistry·Baasanjav UranbilegHiroto Okayama
Dec 17, 2009·Human Pathology·Scott D DufresneSteven H Swerdlow
Aug 21, 2013·Cancer Cell·Karoline KollmannVeronika Sexl
Oct 30, 2014·Journal of Clinical Immunology·Andrew S BrohlAndrew L Snow
May 15, 2020·International Journal of Cancer. Journal International Du Cancer·Sofie NebenfuehrVeronika Sexl
Apr 9, 2020·International Journal of Molecular Sciences·Iris Z UrasKaroline Kollmann
Nov 12, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chien-Feng LiHsuan-Ying Huang

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