Clinicopathologic features of chronic nonspecific multiple ulcers of the small intestine

Clinical Journal of Gastroenterology
Motohiro EsakiTakayuki Matsumoto

Abstract

Chronic nonspecific multiple ulcers of the small intestine is a rare but distinct clinical condition, characterized by multiple small intestinal ulcers of nonspecific histology and chronic, persistent gastrointestinal bleeding without nonsteroidal anti-inflammatory drug use. However, because of the term "nonspecific" in its nomenclature, some gastroenterologists have misinterpreted the disease as the condition with small intestinal ulcers caused by undetermined etiologies without considering clinical features. Such misinterpretation has led to the heterogeneity of clinicopathologic features of the disease, as well as to ambiguity regarding a possible genetic contribution. It thus seems necessary to recognize the clinical entity of the disease precisely to avoid misinterpretation. In this review, we describe the clinicopathologic features, differential diagnosis, and the possibility of a genetic contribution to the disease.

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Citations

Jul 29, 2016·Journal of Pediatric Gastroenterology and Nutrition·Keiichi UchidaTomoaki Taguchi
Sep 8, 2020·Pathology International·Hirofumi WatanabeHironobu Sasano
Aug 2, 2018·World Journal of Gastroenterology : WJG·Junji UmenoMotohiro Esaki
Apr 24, 2019·World Journal of Gastroenterology : WJG·Yuichi MatsunoTakayuki Matsumoto
Dec 18, 2020·Internal Medicine·Yoshikazu TsuzukiHiroyuki Imaeda

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