Clinicopathologic features of IgA-dominant infection-associated glomerulonephritis: a pooled analysis of 78 cases

American Journal of Nephrology
Ru BuGuang-yan Cai

Abstract

IgA-dominant infection-associated glomerulonephritis (IgA-dominant IAGN) is a unique form of glomerulonephritis. There are numerous case reports in the literature. However, the risk factors, treatment approach, and outcomes of the disease are not clearly characterized. We completed a pooled analysis based on published literature. Clinical features, laboratory findings, and histopathological changes were analyzed. A logistic regression model was employed to identify the determinants of disease outcome, for example, end-stage renal disease (ESRD) or death. Seventy-eight patients with IgA-dominant IAGN from 28 reports were analyzed. All of these patients showed granular IgA deposits predominantly along the glomerular peripheral capillary walls using immunofluorescence and majority showed subepithelial 'hump-shaped' electron-dense deposits using electron microscopy. The majority of patients had hematuria (76/78), proteinuria (75/78), acute kidney injury (AKI) (66/78) and hypocomplementemia (43/75) without a previous history of renal disease. All of the patients had clinical infections at the time of presentation. Skin infections (19/78) and visceral abscesses (15/78) were frequently encountered, and staphylococcus was the most comm...Continue Reading

Citations

Jan 24, 2016·Journal of Nephrology·Cristiana RollinoRosanna Coppo
Oct 6, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Werner Keenswijk, Johan Vande Walle
Nov 9, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Anjali A SatoskarTibor Nadasdy
Aug 10, 2019·PloS One·Bogdan ObrișcăGabriel Mircescu
Feb 26, 2020·BMC Nephrology·Precil Diego Miranda de Menezes NevesViktoria Woronik
Aug 11, 2019·Nature Reviews. Nephrology·Anjali A SatoskarTibor Nadasdy
Nov 1, 2018·The New England Journal of Medicine·Nicholas S DowningJoseph Loscalzo
Jan 24, 2019·Journal of Clinical Medicine·Alejandra Oralia Orozco GuillénMagdalena Madero
Dec 15, 2020·The American Journal of the Medical Sciences·Arun RajasekaranDana V Rizk
Aug 29, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Daniel S GrosserAgnes B Fogo

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