Clinicopathologic features of primary cutaneous melanoma: a single centre analysis of a Swiss regional population

European Journal of Dermatology : EJD
Markus V HepptJivko Kamarashev

Abstract

Melanoma is a common type of skin cancer with poor survival in advanced stages. Screening efforts aim to detect and tackle tumors at an early stage. However, regional population-based data at the time of initial diagnosis are sparse. To analyse clinical and pathologic tumor characteristics in a Swiss population. Melanoma samples diagnosed at a large Swiss academic department were evaluated for demographic, clinical and histopathologic data. We analysed a total of 254 melanoma samples. In situ tumors were more common in females than in males (70.6% vs. 29.4%; p = 0.0032). The acro-lentiginous subtype was more common in in situ compared to invasive tumors (14.7% vs. 5.5%; p = 0.0011). Invasive tumors showed a preference for male gender in patients beyond 60 years of age (p = 0.0080). The most frequent anatomic sites were the trunk in males and the legs in females. Regression was more common in males than in females (35.2% vs. 11.7%; p = 0.0001). Breslow's thickness correlated significantly with age but not with gender. Ulceration was common in tumors thicker than 2.01 mm (48.4%; p = 0.0001). Regression was frequently detected in melanomas thinner than 1.00 mm (29.3%; p = 0.0263). Screening efforts should target elderly patients. ...Continue Reading

Citations

Jun 12, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·L TognettiP Rubegni

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