Clinicopathologic findings in (anti-FcepsilonR1alpha) autoimmune-related chronic urticaria

Journal of Cutaneous Pathology
Theera RojanapremsukThomas Cibull

Abstract

One cause of chronic urticaria is autoreactivity which is diagnosed by detecting autoantibodies against the IgE receptor alpha subunit (anti-Fc R1alpha). To compare the histopathologic features of chronic urticaria patients testing positive for anti-IgE receptor antibody (Ab) to those testing negative. Totally, 438 patients with a clinical presentation of chronic urticaria (2011-2013) had anti-IgE receptor Ab tested and 37 of those patients had skin biopsy. We evaluated microscopic features including: spongiosis, dermal edema, presence of mast cells, density of lymphocytic infiltration, predomination of eosinophils/neutrophils; intravascular neutrophils and presence of vasculitis. The aforementioned features were compared between negative and positive anti-IgE receptor Ab groups. Of 37 patients , 69% were women and 31% were men. 49% had positive anti-IgE receptor Ab and 51% had negative anti-IgE receptor Ab. In the positive anti-IgE receptor Ab group, 83% showed intravascular neutrophils. Eosinophil predominance was identified in 72% and neutrophil predominance was identified in 28%. In the negative anti-IgE receptor Ab group, 89% showed intravascular neutrophils. Eosinophil predominance was identified in 53% and neutrophil pre...Continue Reading

References

Jan 1, 1990·International Archives of Allergy and Applied Immunology·C E GrattanR K Winkelmann
May 29, 1998·The British Journal of Dermatology·E ToppeB M Henz
Jan 19, 2002·The Journal of Allergy and Clinical Immunology·Yoko Kikuchi, Allen P Kaplan
Jan 18, 2006·Archives of Dermatology·Steven KossardBarbara Wilkinson
Feb 18, 2010·Indian Journal of Dermatology·C L Goh, K T Tan

❮ Previous
Next ❯

Citations

Nov 14, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Jorge SánchezRicardo Cardona
Feb 23, 2017·Pharmacotherapy·Alessandro TonacciSebastiano Gangemi
Sep 21, 2017·Clinical Reviews in Allergy & Immunology·Daniel Elieh Ali Komi, Korneel Grauwet
Mar 30, 2019·Recent Patents on Inflammation & Allergy Drug Discovery·Kam L HonSteven K Loo
Sep 19, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Melanie Mitsui Wong, Paul Kevin Keith
Sep 1, 2019·The Journal of Allergy and Clinical Immunology. in Practice·Pavel KolkhirMarcus Maurer
Apr 7, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Ana M Giménez-ArnauAllen P Kaplan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Current Allergy and Asthma Reports
D C Napoli, T M Freeman
Revista alergia Mexico : organo oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
D I Ramírez Aragón
Indian Journal of Dermatology, Venereology and Leprology
Mamatha GeorgeSmitha Prabhu
© 2022 Meta ULC. All rights reserved