Clinicopathologic significance of LAIR-1 expression in hepatocellular carcinoma

Current Problems in Cancer
Xiaojie WuJiangnan Xue

Abstract

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is an immune inhibitory receptor which is expressed within most types of hematopoietic cells and negatively regulates immune responses. Recently, we found LAIR-1 expression to be present within tumors of nonhematopoietic lineages. However, the roles of LAIR-1 in hepatocellular carcinoma (HCC) have yet to be examined. The purpose of this study was to investigate the expression of LAIR-1 in HCC tissue and assess its clinical significance at this site. Expression levels of LAIR-1 within HCC samples collected from 90 patients and compared with that of slides of normal liver tissue collected from 9 non-HCC patients were measured by immunohistochemistry using tissue microarrays. A semiquantitative score was assigned, as was based on staining intensity and percent of positive cells and a Spearman Rank correlation test was used to assess any potential significant correlations between LAIR-1 expression and clinicopathological factors. Overall survival analysis was performed using the Kaplan-Meier and Log Rank statistical test. LAIR-1 expression was detected in cancer tissue and adjacent tumor tissue, but not in normal liver tissue. The percent of LAIR-1-positive expression in ...Continue Reading

Citations

Feb 27, 2020·Cellular and Molecular Life Sciences : CMLS·Henrik J JürgensenDaniel H Madsen
Nov 6, 2020·International Journal of Molecular Sciences·Mira ParkTaesung Park
Jun 19, 2021·The Journal of Allergy and Clinical Immunology·Doumet Georges HelouOmid Akbari

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