Clinicopathologic significance of mitotic arrest defective protein 2 overexpression in hepatocellular carcinoma

Human Pathology
Shu-Hui ZhangYu-Jia Wang

Abstract

Mitotic arrest defective protein 2 (MAD2) gene plays a central role in the mitotic checkpoint. Elevated MAD2 expression was observed in a number of human malignancies; its role in the development of hepatocellular carcinoma is still not understood and is controversial. The purpose of this study was to investigate the clinicopathologic significance of MAD2 expression in hepatocellular carcinoma. The MAD2 protein and its messenger RNA levels were measured in hepatocellular carcinomas, high-grade dysplastic nodules, and their paired nontumorous liver tissues by quantitative real-time polymerase chain reaction, Western blot, and immunohistochemistry. The results showed that MAD2 at both messenger RNA and protein levels was overexpressed in 8 of 9 high-grade dysplastic nodules and in 51 of 58 hepatocellular carcinomas, including 12 of 14 unifocal small hepatocellular carcinomas. There was a tendency for MAD2 expression to increase in the process of this multistep carcinogenesis. A significantly high tumor MAD2 immunostaining was associated with the progression of histologic grade and the overall low survival. In conclusion, MAD2 is overexpressed frequently in hepatocellular carcinoma, including high-grade dysplastic nodules and earl...Continue Reading

References

Apr 10, 1997·Nature·C LengauerB Vogelstein
Feb 2, 1999·Oncogene·M SalvucciB Debuire
Oct 19, 1999·Journal of Computer Assisted Tomography·Y ZhangY Nakashima
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y W LinF J Lu
Sep 27, 2001·Japanese Journal of Cancer Research : Gann·K TanakaT Nobori
Nov 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E GarberI Petersen
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 12, 2002·Molecular Biology of the Cell·Xin ChenPatrick O Brown
Sep 3, 2003·Nature Reviews. Cancer·Harith RajagopalanChristoph Lengauer
Dec 9, 2003·The Journal of Biological Chemistry·Xiangbing MengZhiyuan Shen
Sep 1, 2004·Biochemical and Biophysical Research Communications·Ray Kit NgMary Miu Yee Waye
Dec 14, 2004·Journal of Biomedical Science·Karen Man-Fong SzeIrene Oi-Lin Ng
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roman RouzierLajos Pusztai
Oct 1, 2005·Nature Reviews. Cancer·Geert J P L KopsDon W Cleveland
Dec 13, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Zhi-Hong XianMeng-Chao Wu
Aug 25, 2006·Nature Reviews. Cancer·Paraskevi A Farazi, Ronald A DePinho
Oct 18, 2006·International Journal of Cancer. Journal International Du Cancer·Caroline RimkusKlaus-Peter Janssen
Dec 27, 2006·Cancer Cell·Rocío SotilloRobert Benezra
May 23, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Xia TaoShu-Hui Zhang
May 15, 2008·Pathology International·Masanori HisaokaHiroshi Hashimoto

❮ Previous
Next ❯

Citations

Aug 2, 2011·Annual Review of Cell and Developmental Biology·Teresa Davoli, Titia de Lange
Sep 9, 2011·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Ling YuJianhua Liu
Mar 8, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tatsuya KatoMitsuhito Kaji
Feb 6, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ling YuJia-Lu Chen
Jun 4, 2013·Biomaterials·Pauline ResnierCatherine Passirani
Jun 11, 2011·Current Biology : CB·John R DaumGary J Gorbsky
Jul 8, 2018·International Journal of Cancer. Journal International Du Cancer·Giorgia SimonettiGiovanni Martinelli
Mar 14, 2019·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Zide ChenHongyan Liu
Sep 3, 2013·Virchows Archiv : an International Journal of Pathology·Jung-Woo ChoiYoung-Sik Kim
Jun 29, 2012·Oncology Letters·Yusuke NakanoOsamu Ishiko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Related Papers

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Tatsuya KatoMitsuhito Kaji
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Zhi-Hong XianMeng-Chao Wu
© 2022 Meta ULC. All rights reserved