PMID: 7538690Jan 1, 1995Paper

Clinicopathologic studies of an eye after submacular membranectomy for choroidal neovascularization

Retina
J K HsuW R Green

Abstract

Submacular membranectomy has been suggested as an alternative treatment for subfoveal choroidal neovascularization (CNV). Clinicopathologic features of the right eye of a 59-year-old man with recurrent subfoveal CNV who underwent submacular membranectomy after two unsuccessful laser photocoagulation treatments are reported. The surgically excised subfoveal membrane was sectioned serially and evaluated by light microscopy. The globes were obtained postmortem and serial sectioned through the macula and optic nerve head for light microscopy. Ultrastructural study of a tissue section in the center of the lesion was performed. Histopathologic study of the surgically excised membrane disclosed a thin two-component fibrovascular membrane with the larger component internal to residual retinal pigment epithelium and basal laminar deposit. Photoreceptor outer segments were present on the internal surface of the membrane near one margin. Light and electron microscopic study of the postmortem globe revealed a very thin subfoveal subretinal pigment epithelial fibrovascular membrane with loss of photoreceptor cell layer in a central 0.5 mm area, loss of outer segments, reduction of inner segments, and thinning of the outer nuclear layer in t...Continue Reading

Citations

Apr 15, 2009·Archives of Ophthalmology·Volker EnzmannSuzanne T Ildstad
Dec 12, 2003·Experimental Eye Research·Hao WangMarco A Zarbin
Mar 14, 2003·Experimental Eye Research·Debra S LeonardMarco A Zarbin
Apr 13, 2002·Drugs & Aging·Morten la CourMogens Holst Nissen
Jun 8, 2004·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Sundara V RamanMichael A Samuel
Mar 12, 2004·American Journal of Ophthalmology·Hans E Grossniklaus, W Richard Green
May 12, 2010·Experimental Eye Research·Olga Lucia GamboaNoemi Lois
Oct 9, 2007·Progress in Retinal and Eye Research·Lyndon da CruzPete Coffey
Jan 27, 2005·Experimental Eye Research·Vamsi K GullapalliMarco A Zarbin

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