PMID: 8943177Jan 1, 1997Paper

Clinicopathologic study of angiogenesis in Japanese patients with breast cancer

World Journal of Surgery
T KatoM Aiba

Abstract

To evaluate the clinicopathologic significance of angiogenesis as a prognostic factor and the objective methods for evaluating angiogenesis, we immunohistochemically stained a representative section of breast tumors with factor VIII-related antigen staining. There were 109 patients with primary breast cancer from 1971 to 1979. The two methods of identifying angiogenesis were the average microvessel count per square millimeter (AMC) and the highest microvessel count per square millimeter (HMC). There was no relation between microvessel count (AMC or HMC) or age, menopausal status, clinical tumor size (T), histologic classification, nuclear grade, node status, histologic grade (HG), mitosis index, or lymphatic invasion (LI). There was a relation between microvessel count and blood vessel invasion (BVI) (HMC:p = 0.0007) and tumor necrosis (TN) (HMC:p = 0.0050). Univariate analysis showed that AMC or HMC was a statistically significant predictor of overall survival in all patients (p = 0.0086 and p = 0.0307, respectively). Multivariate analysis showed that AMC was an independent predictor of node status when we fitted a model with node status, BVI, and either AMC or HMC; but HMC was not independent. However, when we fitted a model ...Continue Reading

Citations

Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·T KatoT Kasajima
Nov 25, 2003·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shinichi TsutsuiShoichi Era
Mar 5, 1999·Breast Cancer Research and Treatment·I C Henderson, A J Patek
May 5, 2001·Breast Cancer Research and Treatment·T KatoT Kasajima
Dec 13, 2002·International Journal of Cancer. Journal International Du Cancer·Christian SfiligoiMichele De Bortoli
Dec 20, 2015·International Journal of Toxicology·Lillian C BeckerF Alan Andersen
Nov 5, 1999·The Journal of Pathology·J A BeliënJ P Baak
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S K ChiaA L Harris
Apr 24, 2019·British Journal of Cancer·Casper ReijnenJohanna M A Pijnenborg
Feb 6, 2020·International Journal of Molecular Sciences·Eleonora VecchioIleana Quinto

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