Clinicopathologic study of mixed adenoneuroendocrine carcinomas of hepatobiliary organs.

Virchows Archiv : an International Journal of Pathology
Kenichi HaradaYasuni Nakanuma

Abstract

Neuroendocrine neoplasms in hepatobiliary organs are very rare, but several cases of mixed adenoneuroendocrine carcinoma (MANEC) have been reported. In this study, we characterized the neuroendocrine component of biliary MANEC. A total of 274 cases of biliary cancer including 17 intrahepatic cholangiocarcinomas (CCs), 15 hepatic hilar CCs without preceding hepatobiliary disease, 55 hepatic hilar CCs with hepatolithiasis, 49 gallbladder cancers, 53 extrahepatic CCs, and 85 hepatocellular carcinomas were examined for a neuroendocrine component using immunohistochemistry with neuroendocrine markers (chromogranin A and synaptophysin). In the MANEC cases, in addition to a close histological examination, the proliferative activity and the expression of somatostatin receptor 2A were also evaluated. In addition to an ordinary adenocarcinoma, a neuroendocrine component occupying more than 30% of the entire tumor was also found in 4% (2/55 cases) of hepatic hilar cholangiocarcinomas with hepatolithiasis, 10% (5/49 cases) of gallbladder cancers, and 4% (2/53 cases) of extrahepatic cholangiocarcinomas, but not in the intrahepatic cholangiocarcinomas, hilar cholangiocarcinomas without preceding hepatobiliary disease, and hepatocellular carc...Continue Reading

References

Nov 25, 2003·Pathology International·Kazuya KuraokaWataru Yasui
May 22, 2004·Annals of the New York Academy of Sciences·Günter KlöppelPhilipp U Heitz
Apr 28, 2006·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Tetsuya ShimizuZenya Naito
May 4, 2006·Virchows Archiv : an International Journal of Pathology·Gabriella NesiFrancesco Tonelli
Aug 29, 2006·Surgery Today·Atsuo TsuchiyaNorio Inoue
Sep 13, 2006·Virchows Archiv : an International Journal of Pathology·G RindiUNKNOWN European Neuroendocrine Tumor Society (ENETS)
Mar 27, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Günter Klöppel
Sep 18, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marco VolanteMauro Papotti

❮ Previous
Next ❯

Citations

May 30, 2013·World Journal of Gastroenterology : WJG·Ichiro OnishiYasuni Nakanuma
Oct 22, 2013·World Journal of Surgical Oncology·Toshihiro KitajimaHarushi Udagawa
Feb 19, 2015·Cytopathology : Official Journal of the British Society for Clinical Cytology·R YadavV K Iyer
May 13, 2015·Best Practice & Research. Clinical Gastroenterology·Yasuni Nakanuma, Yuko Kakuda
Jul 5, 2016·Case Reports in Gastrointestinal Medicine·Sali Priyanka AkhileshWagle Prasad Kashinath
Sep 30, 2016·Archives of Pathology & Laboratory Medicine·Andres M Acosta, Elizabeth Louise Wiley
Nov 25, 2016·Journal of Clinical Pathology·Yoriko NomuraHirohisa Yano
Jun 4, 2019·The Journal of International Medical Research·Hai-Wen ZhangGuang-Yi Wang
Feb 21, 2013·Journal of Clinical Pathology·Kenichi HaradaYasuni Nakanuma
Aug 25, 2020·The Journal of International Medical Research·Xu LiGuoyue Lv
Sep 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Run-Sheng GuoYue-Yu Chen
Feb 27, 2015·World Journal of Gastroenterology : WJG·Zhen HuangJian Ao
Apr 4, 2015·International Journal of Surgical Pathology·Andrés Martin AcostaElizabeth Louise Wiley
Jun 23, 2016·Molecular and Clinical Oncology·Nicole MaxCord Langner
Mar 24, 2018·SAGE Open Medical Case Reports·Safak Gül-KleinFelix Aigner
Jul 26, 2019·Clinical Journal of Gastroenterology·Shingo YoshimachiMichiaki Unno
Mar 25, 2019·World Journal of Surgical Oncology·Adam SkalickýOndřej Troup
Jul 8, 2020·Surgical Case Reports·Takashi MaedaHiroyuki Matsuda
Dec 2, 2020·BMJ Case Reports·Hanako SasakiYasunori Fujimoto
May 8, 2021·World Journal of Clinical Oncology·Yiannis Petros DimopoulosMetin Ozdemirli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.