Clinicopathologic study of vascular endothelial growth factor, thrombospondin-1, and microvessel density assessed by CD34 in patients with stage III ovarian carcinoma

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
V KaravasilisN Pavlidis

Abstract

The aim of the study was to investigate angiogenesis in patients with advanced-stage ovarian carcinoma. We used paraffin-embedded tumor tissues from 33 patients diagnosed with FIGO III ovarian cancer who had optimal surgery and received platinum-based chemotherapy. The tissue expression of CD34, vascular endothelial growth factor (VEGF), and thrombospondin-1 (TSP-1) was assessed immunohistochemically. CD34 stained hot spot areas were used to evaluate tumor microvessel density (MVD). VEGF and TSP-1 were assessed by semiquantitative methods. The studied molecules were investigated for relationship with standard clinicopathologic parameters. MVD count was high: median value of 39, range 12-143 microvessels/mm2. VEGF was present in all cases and stained strong in 91%. Stroma staining for TSP-1 was weak in 79% of the cases, strong in 6%, and absent in five (15%). We did not find correlations between the three studied markers and histologic type or tumor grade. MVD score did not relate to VEGF or TSP-1. We only observed a trend toward a longer survival in patients with tumors expressing high TSP-1 (60 vs. 36 months, P= 0.1). Proangiogenetic factor VEGF is highly expressed in advanced-stage ovarian carcinomas. The findings of this stu...Continue Reading

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Citations

Jun 16, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Liisa LaatioUlla Puistola
Dec 6, 2011·The Journal of Obstetrics and Gynaecology Research·Wei WeiXun Qu
May 7, 2015·Connective Tissue Research·Denise PinessiAndrea Resovi
Jun 12, 2013·International Journal of Molecular Sciences·Yasuyoshi Miyata, Hideki Sakai

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