Clinicopathological analysis in patients with neuroendocrine tumors that metastasized to the brain

BMC Cancer
Jiro AkimotoToshitaka Nagao

Abstract

A neuroendocrine tumor (NET) can develop anywhere in the body, but is mainly found in the pancreas, gastrointestinal tract, and lungs. This report is a retrospective study of the clinicopathological features of NET patients with brain metastasis whose tissue diagnosis was made at our hospital. Patients with brain metastasis evidenced by clinical records and images were accumulated among 302 patients in whom tissue diagnosis of NETs was made at our hospital between 2008 and 2013. In the patients, the primary lesion, pathological classification, pattern of metastasis, details of treatment, and outcomes were analyzed. Brain metastasis was observed in 31 patients (10.3%). The primary lesion was in the lungs in 26 patients (83.9%), and the mammary glands, esophagus, and uterus in 1 patient each. Primary lesions were unknown in 2 patients, including 1 patient in whom NETs were detected in the lymph nodes alone. Pathological classification of the primary lesion was NET Grade 2 (Ki-67: 3 to 20%) in 3 patients and neuroendocrine carcinoma (NEC, Ki-67: ≥ 21%) in 26 patients. The median period from onset of the primary lesion up to diagnosis of brain metastasis was 12.8 months, and the brain lesion preceded brain metastasis in 6 patients....Continue Reading

References

Oct 15, 2008·Cancer·Oyvind HausoIrvin M Modlin
May 11, 2010·Neuroendocrinology·Marianne PavelUNKNOWN Palma de Mallorca Consensus Conference Participants
Jul 29, 2010·Pancreas·Aaron I VinikUNKNOWN North American Neuroendocrine Tumor Society (NANETS)
Jul 13, 2011·Surgical Neurology International·Atsushi TsuguMitsunori Matsumae
Feb 1, 2012·Case Reports in Oncology·Simon B ZeichnerAlicia Hirzel
May 15, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jong-Mu SunKeunchil Park
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Jan 1, 2010·Cancers·Alexander Chi, Ritsuko Komaki
Jan 7, 2014·PloS One·Hui-Jen TsaiJeffrey S Chang
May 3, 2014·Therapeutic Advances in Medical Oncology·Chiara D'AntonioFilippo de Marinis

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Citations

Sep 21, 2019·BMJ Case Reports·Clay T ReedJan Buckner
May 3, 2019·BMC Neurology·Julie R BloomJonathan Cheponis
Apr 12, 2021·International Journal of Surgery Case Reports·Turki ElarjaniMaher Hassounah
Apr 20, 2021·Frontiers in Endocrinology·Joshua A CuocoSandeep Mittal
Sep 30, 2021·Experimental and Therapeutic Medicine·Adina GhemigianAna Valea

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