Clinicopathological analysis of biopsy-proven diabetic nephropathy based on the Japanese classification of diabetic nephropathy

Clinical and Experimental Nephrology
Kengo FuruichiResearch Group of Diabetic Nephropathy, Ministry of Health, Labour and Welfare of Japan, and Japan Agency for Medical Resear

Abstract

The Japanese classification of diabetic nephropathy reflects the risks of mortality, cardiovascular events and kidney prognosis and is clinically useful. Furthermore, pathological findings of diabetic nephropathy are useful for predicting prognoses. In this study, we evaluated the characteristics of pathological findings in relation to the Japanese classification of diabetic nephropathy and their ability to predict prognosis. The clinical data of 600 biopsy-confirmed diabetic nephropathy patients were collected retrospectively from 13 centers across Japan. Composite kidney events, kidney death, cardiovascular events, all-cause mortality, and decreasing rate of estimated GFR (eGFR) were evaluated based on the Japanese classification of diabetic nephropathy. The median observation period was 70.4 (IQR 20.9-101.0) months. Each stage had specific characteristic pathological findings. Diffuse lesions, interstitial fibrosis and/or tubular atrophy (IFTA), interstitial cell infiltration, arteriolar hyalinosis, and intimal thickening were detected in more than half the cases, even in Stage 1. An analysis of the impacts on outcomes in all data showed that hazard ratios of diffuse lesions, widening of the subendothelial space, exudative l...Continue Reading

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Citations

Mar 6, 2019·Diabetes Care·Masayuki YamanouchiUNKNOWN Research Group of Diabetic Nephropathy, the Ministry of Health, Labour and Welfare, and the Japan Agency for Medical Researc
Jun 7, 2020·BMJ Open Diabetes Research & Care·Kengo FuruichiTakashi Wada
Nov 24, 2018·Clinical and Experimental Nephrology·Takafumi YamakawaToshiyuki Imasawa
Apr 30, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ryo ZamamiYusuke Ohya
Jul 27, 2020·Endocrinology, Diabetes & Metabolism·Akinori HaraTakashi Wada
Mar 23, 2018·Clinical and Experimental Nephrology·Kengo FuruichiTakashi Wada
Feb 10, 2021·Journal of Diabetes and Its Complications·Masashi IshizuMunehide Matsuhisa
Feb 20, 2021·Clinical and Experimental Nephrology·Yoshifumi UbaraUNKNOWN Committee of Practical Guide for Kidney Biopsy 2020
Jul 31, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Junmin WangGuang Ji
May 25, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Masayuki YamanouchiUNKNOWN Research Group of Diabetic Nephropathy, the Ministry of Health, Labour and Welfare, and the Japan Agency for Medical Researc
Aug 8, 2021·Nature Reviews. Nephrology·Megumi OshimaTakashi Wada
Jan 23, 2022·Journal of Nephrology·Shunsuke GotoShinichi Nishi

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