Clinicopathological and immnuohistochemical findings in a series of folliculosebaceous cystic hamartoma

Journal of Cutaneous Pathology
Jose M Suarez-PeñarandaJerónimo Forteza-Vila

Abstract

Folliculo-sebaceous cystic hamartoma (FSCH) is an uncommon skin condition presenting as a slow-growing papulo-nodular lesion, in or around the nose. Most cases are not clinically suspected and only histopathological examination allows the diagnosis. Pathological features include a dermal-located infundibulo-cystic structure with sebaceous glands radiating around, a stromal component encircling the epithelial structures, with clefts between the lesional epithelial and stromal parts, as well as between this and the adjacent dermis. We report eight patients with the diagnosis of FSCH (5 females and 3 males), with ages ranging from 35 to 77 years. Most cases (5 out of 8) were located in or around the nose and sizes were comprised between 0.6 and 1.2 cm. Lesions had grown for long periods of time, up to ten years in one case. Immunohistochemistry showed staining for p63 in the epithelial component of all lesions, while CD10 was only present in some sebocytes. CD34 and Factor XIIIa positive cells were present in the lesional stroma. Staining for androgen and alpha-estrogen receptors was also usually noticed. FCSH is a hamartomatous skin lesion, clinically indistinct but with well-defined histopathological features. Immunohistochemist...Continue Reading

References

Dec 1, 1980·Journal of Cutaneous Pathology·G Plewig
Apr 1, 1995·Journal of Cutaneous Pathology·N ShikataA Tsubura
Apr 1, 1994·Journal of Cutaneous Pathology·O YamamotoJ Bhawan
Nov 1, 1993·The Journal of Dermatology·T YamamotoK Nishioka
Jan 1, 1996·Journal of the American Academy of Dermatology·S F Templeton
Feb 1, 1996·The American Journal of Dermatopathology·F AloiM Pippione
Jul 1, 1997·The Journal of Dermatology·M Toyoda, M Morohashi
Jun 27, 1998·Pathology·P K RamdialA Madaree
Oct 9, 1998·Journal of Cutaneous Pathology·T Schulz, W Hartschuh
Nov 13, 1998·Dermatology : International Journal for Clinical and Investigative Dermatology·J L Bolognia, B J Longley
Mar 19, 1999·Journal of Cutaneous Pathology·R S SimónE Sánchez Yus
Jun 15, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·K S HamiltonB R Smoller
Oct 27, 2001·International Journal of Dermatology·M A El-DaroutyH M Mashaly
Feb 27, 2004·Journal of Cutaneous Pathology·David E SturtzDouglas R Fullen
Sep 25, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Doina IvanVictor G Prieto
Dec 25, 2004·The American Journal of Dermatopathology·Kazuhiro YadaShigeo Yokoyama
Jan 15, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·D Brasanac, I Boricic
Jul 12, 2005·Endocrine Journal·Yoshiyuki KariyaHironobu Sasano
Jul 28, 2005·Clinical and Experimental Dermatology·C-H YangH-S Hong
Nov 29, 2005·Clinical and Experimental Dermatology·S TanimuraH Shimizu
Apr 20, 2006·The Journal of Dermatology·Manabu HamadaMasutaka Furue
Jun 17, 2006·The American Journal of Dermatopathology·Seung Yoon LeeSook Ja Son
Jan 17, 2007·Journal of the American Academy of Dermatology·Hee KangKye Yong Song
May 17, 2007·Journal of the American Academy of Dermatology·Payam SaadatManjunath S Vadmal

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Citations

Sep 9, 2015·Journal of Cutaneous Pathology·Juan C H López-TakegamiAlmut Böer-Auer
Sep 17, 2009·The American Journal of Dermatopathology·Noriyuki MisagoYutaka Narisawa
Oct 5, 2010·The American Journal of Dermatopathology·Shin-ichi AnsaiSeiji Kawana
Feb 1, 2019·The American Journal of Dermatopathology·Peter E WilkinsonProkopios P Argyris
Jun 8, 2018·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Tomu OkadaIkuma Kato
Feb 24, 2012·Ear, Nose, & Throat Journal·Fabiana Pirani CarneiroAna Emília Borges de Azevedo
Nov 21, 2015·The American Journal of Dermatopathology·Catherine M NguyenDavid Cassarino
Feb 26, 2021·Pediatric Dermatology·Ana María Sáenz, Elizabeth Ball

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