Clinicopathological and immunohistochemical features of a sebaceous carcinoma arising within a benign dermoid cyst of the ovary

Virchows Archiv : an International Journal of Pathology
Alfredo Ribeiro-SilvaLuiz Orlando M Ré

Abstract

Pure sebaceous neoplasms arising in dermoid cysts of the ovary are exceedingly rare. A 63-year-old female with abdominal swelling and pain underwent a right salpingo-oophorectomy that showed a unilocular cyst weighing 830 g and measuring 15x12x10 cm, filled with sebaceous material containing a few hair shafts. The cyst wall exhibited plaques protruding into the cavity of the cyst. Microscopy revealed a dermoid cyst with nests and lobules of atypical and infiltrating sebaceous cells surrounded by basaloid cells. The tumor cells stained diffusely for high-molecular-weight cytokeratins and focally for cytokeratin 7, cytokeratin 19, epithelial membrane antigen and carcinoembryonic antigen in the immunohistochemistry study. Low-molecular-weight cytokeratins, cytokeratin 20, vimentin, S100, p63, estrogen receptor, progesterone receptor, p53 and c-erbB-2 were negative in tumoral cells. The proliferative labeling index (Ki67 and proliferating cell nuclear antigen) was low. Basal cell carcinoma with sebaceous differentiation and sebaceoma must be considered in the differential diagnosis. However, the presence of obvious malignant sebaceous differentiation in nearly every tumor nest and lack of peripheral palisading and peri-tumoral myxo...Continue Reading

Citations

May 30, 2006·Journal of Clinical Pathology·M A den BakkerP C Ewing-Graham
Jun 21, 2011·Annals of Diagnostic Pathology·Jason SmithThomas Robertson
Sep 7, 2013·Korean Journal of Pathology·Hyo Jeong AnSoo Jin Jung
Mar 15, 2016·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Alexandra A MoullaMona El-Bahrawy
Jul 27, 2011·Neurosurgery·Mark J WinderMarc R Mayberg
Sep 1, 2018·Journal of Ovarian Research·Kazuya MaedaMasahide Ohmichi
Mar 5, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Hai-Li ZhuHong Shen

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