Clinicopathological and immunohistochemical analysis of spindle cell squamous cell carcinoma of the tongue: a rare case

Einstein
Diego Filipe Bezerra SilvaCassiano Francisco Weege Nonaka

Abstract

Spindle cell squamous cell carcinoma of the tongue is a rare variant of squamous cell carcinoma. This paper reports the case of a spindle cell squamous cell carcinoma of the tongue, in a 64-year-old male patient, and presents a review of the etiopathogenesis, clinicopathological and immunohistochemical features and treatment of the malignancy. The patient presented for evaluation of a painful swelling on his tongue. Extraoral examination revealed palpable submandibular and superior cervical lymph nodes. Based on the presumptive diagnoses of squamous cell carcinoma or malignant salivary gland neoplasm, an incisional biopsy was performed. Histopathological analysis showed a proliferation of atypical spindle cells, exhibiting extensive pleomorphism. Tumor cells were positive for vimentin, P53 and alpha-smooth muscle actin, focally positive for epithelial membrane antigen and P63, and negative for pan-cytokeratin (AE1/AE3), CK7, CD138, CD34, CD56, and S-100. The positivity index for Ki-67 was approximately 40%. The diagnosis of spindle cell squamous cell carcinoma was established and the patient was referred to a head and neck surgery service. In the oral cavity, spindle cell squamous cell carcinoma of the tongue is an aggressive v...Continue Reading

References

Dec 1, 1980·Oral Surgery, Oral Medicine, and Oral Pathology·G L Ellis, R L Corio
Jun 25, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·James S LewisSamir El-Mofty
Nov 14, 2006·Journal of the Chinese Medical Association : JCMA·Hsing-Hao SuChia-Jung Chen
Dec 17, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mário José RomañachFábio Ramôa Pires
Nov 13, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Phuong T NguyenTakashi Takata
Jul 24, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Tristan C BiceMatthew C Miller
Jul 13, 2017·Virchows Archiv : an International Journal of Pathology·Nina ZidarVojko Didanovič

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Methods Mentioned

BETA
biopsies
biopsy

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Carcinoma, Squamous Cell

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