Clinicopathological and molecular characteristics associated with PD-L1 expression in non-small cell lung cancer: a large-scale, multi-center, real-world study in China.

Journal of Cancer Research and Clinical Oncology
Qiang ZhengYuan Li

Abstract

The study aimed to evaluate the clinicopathological and molecular profiles associated with programmed death ligand 1 (PD-L1) expression in non-small cell lung cell (NSCLC) in a large-scale, multi-center, real-world Chinese cohort. A total of 6295 NSCLC specimens from six centers in China were analyzed by PD-L1 (22C3) assay. PD-L1 expression in tumor cells (TCs) was classified as negative (TPS expression in < 1% of TCs), low (TPS in 1-49% of TCs), or high (TPS in ≥ 50% of TCs). The status of EGFR mutation was determined by reverse transcription polymerase chain reaction or next-generation sequencing, and ALK and ROS1 translocation was analyzed by immunohistochemistry and fluorescence in situ hybridization. Associations of PD-L1 expression with clinicopathological features and driver mutations were analyzed. Positive PD-L1 expression was more frequently seen in squamous cell carcinoma (SCC) and other histological types of NSCLC compared to adenocarcinoma (AC). In AC, PD-L1 expression was associated with gender, histological type, metastatic status, and pathological features of lymphovascular invasion and visceral pleural invasion. Solid and micropapillary subtypes of AC were more likely to have positive PD-L1 expression compared ...Continue Reading

References

Nov 10, 2013·The Journal of Thoracic and Cardiovascular Surgery·Min Jae ChaHye Sun Hwang
May 24, 2014·Current Opinion in Pulmonary Medicine·Vicente Morales-Oyarvide, Mari Mino-Kenudson
Apr 23, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jong-Mu SunJhingook Kim
Jul 28, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Frank C DetterbeckUNKNOWN IASLC Staging and Prognostic Factors Committee, Advisory Boards, and Participating Institutions
Oct 25, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tiffany G HuynhMari Mino-Kenudson
Dec 4, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Fred R HirschKeith M Kerr
Feb 2, 2018·Therapeutic Advances in Respiratory Disease·Prantesh JainVamsidhar Velcheti
Mar 25, 2018·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yasuto YoneshimaIsamu Okamoto
Apr 24, 2018·Journal of Immunotherapy·Jeng-Sen TsengGee-Chen Chang
Apr 29, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Enrico MunariGiuseppe Bogina
May 26, 2018·The American Journal of Surgical Pathology·Sarah E GradeckiEdward B Stelow
May 26, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ming Sound TsaoFred R Hirsch
Jan 4, 2019·International Journal of Molecular Sciences·Hang XuShaodong Guo
Jun 16, 2019·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jacqueline V AredoHeather A Wakelee
Feb 8, 2020·Journal of Thoracic Disease·Yuichi SaitoEishin Hoshi

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Citations

Aug 28, 2021·Diagnostics·Karmele Saez de GordoaCristina Teixido

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