Clinicopathological and Molecular Characterisation of Crohn's Disease-associated Small Bowel Adenocarcinomas

Journal of Crohn's & Colitis
Xiaoyan LiaoAlexandros D Polydorides

Abstract

Small bowel adenocarcinoma [SBA] is a recognised complication of Crohn's disease [CD], but its low absolute prevalence limits opportunities for clinicopathological characterisation. We compared the clinical, pathological, and molecular features of 48 SBA from patients with CD [CDSBA] and 29 SBAs from patients without CD [NSBA] who underwent treatment at our tertiary care centre between 2000 and 2018. Patients with CDSBA were younger than those with NSBA [mean age, 56 vs 64; p = 0.02]. Males predominated in both groups. Most CDSBA [69%] occurred in the ileum, whereas most NSBA occurred in the duodenum [38%] and jejunum [31%; p < 0.001]. Stage I tumours were more prevalent in the CDSBA [33% vs 3%; p = 0.002], although the rates of Stage IV disease and disease-specific mortality were similar in both groups. CDSBA were less likely to present a discrete mass [35% vs 93%; p < 0.001] and were more often stricturing or fistulising [75% vs 10%, respectively, p < 0.001] than NSBA. Microscopically, CDSBA were relatively heterogeneous, exhibiting at least three distinct growth patterns in 39% compared with 1% of NSBA [p = 0.01]. Low-grade tubuloglandular adenocarcinoma was the predominant pattern in 19% of CDSBA compared with 0% of NSBA [p...Continue Reading

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Citations

Jan 14, 2020·Journal of Crohn's & Colitis·Franck Carbonnel, Magali Svrcek
Jul 1, 2020·Techniques in Coloproctology·T HussainD Liska
Nov 14, 2020·International Journal of Cancer. Journal International Du Cancer·Thomas AparicioPierre Laurent Puig
May 1, 2021·International Journal of Molecular Sciences·Alessandro VanoliAntonio Di Sabatino
May 9, 2021·Virchows Archiv : an International Journal of Pathology·Giovanni ArpaEnrico Solcia
Jun 17, 2021·Applied Immunohistochemistry & Molecular Morphology : AIMM·Dongwei ZhangXiaoyan Liao

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