Clinicopathological and prognostic impact of human epidermal growth factor receptor type 2 (HER2) and hormone receptor expression in uterine papillary serous carcinoma.

Cancer Science
Shinichi TogamiTakahiro Kasamatsu

Abstract

Uterine papillary serous carcinoma (UPSC) is a rare and aggressive variant of endometrial carcinoma. Little is known about the pathological and biological features of this tumor. Human epidermal growth factor receptor 2 (HER2) and hormone receptor (HR) expression have an important role in tumor behavior and clinical outcome, but their relevance in UPSC is not clear. In the present study, the immunohistochemical expression of HER2 and HR was assessed in 27 patients with Stage I disease, 13 with Stage II disease, 25 with Stage III disease, and 6 with Stage IV disease. Correlations between HER2 and HR expression and the clinicopathological parameters of UPSC were evaluated using Cox's univariate and multivariate analyses. For all patients, the 5-year recurrence-free survival (RFS) and overall survival (OS) rates were 51% and 66%, respectively; in patients with Stage I, II, III and IV disease, the RFS and OS were 67%/81%, 59%/77%, 43%/54% and 0%/0%, respectively. Of all 71 patients, 14% (10/71) were positive for HER2 and 52% (37/71) were positive for HR. Overexpression of HER2 was correlated with lower OS (P = 0.01), whereas HR overexpression was correlated with higher OS (P = 0.008). In multivariate models, HER2, HR, and histologi...Continue Reading

References

Jun 1, 1992·The American Journal of Surgical Pathology·M E ShermanR J Kurman
Mar 1, 1982·The American Journal of Surgical Pathology·M HendricksonR Kempson
Sep 1, 1994·Gynecologic Oncology·B A GoffB E Greer
Sep 1, 1996·Clinical Obstetrics and Gynecology·J L Nicklin, L J Copeland
Apr 29, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S KounelisM W Jones
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S MénardG Bonadonna
Oct 18, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R HalperinD Schneider
Jan 17, 2003·Journal of the National Cancer Institute·Gottfried KonecnyDennis J Slamon
Mar 21, 2003·Virchows Archiv : an International Journal of Pathology·A AlkushiC B Gilks
Sep 18, 2003·Journal of the National Cancer Institute·Frédérique SpyratosKamel Hacène
Dec 17, 2003·Gynecologic Oncology·Brian M SlomovitzKaren H Lu
Jul 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian M SlomovitzKaren H Lu
Jul 30, 2005·Cancer Letters·Sridhar K Rabindran
Feb 14, 2006·Gynecologic Oncology·Yoshifumi NakaoTsuyoshi Iwasaka
Mar 4, 2006·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Nov 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Funda Meric-Bernstam, Mien-Chie Hung
Apr 25, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·F E OdicinoS Pecorelli
Jan 19, 2008·Immunology Letters·Elza FriedländerGyörgy Vereb
Aug 22, 2009·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Wei WangVal Gebski
Jun 23, 2010·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Abdulmohsen AlkushiC Blake Gilks
Jul 8, 2010·Gynecologic Oncology·Rajul KothariDavid E Cohn
Nov 16, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sunil BadveJorge S Reis-Filho

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Citations

Jun 15, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Natalia BuzaPei Hui
Mar 1, 2014·Archives of Pathology & Laboratory Medicine·Natalia BuzaAlessandro D Santin
Feb 12, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Georgios AndroutsopoulosGeorgios Decavalas
Dec 8, 2015·Reproduction in Domestic Animals = Zuchthygiene·A L SaraivaM A Pires
Oct 15, 2013·Genes, Chromosomes & Cancer·Natalia Buza, Pei Hui
Sep 10, 2014·Clinical and Translational Science·Sylwia Lapińska-SzumczykAnna J Zaczek
Jun 26, 2015·World Journal of Surgical Oncology·Yanli ZhangJing Sun
Nov 6, 2014·Pathology Oncology Research : POR·Shinichi TogamiHitoshi Tsuda
Oct 25, 2016·Diagnostic Pathology·Jennifer S WooNeda A Moatamed
Dec 18, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Tomoko ShoShohei Shimajiri
Jan 25, 2013·Journal of Gynecologic Oncology·Dong Hoon SuhKyung-Hun Lee
Nov 21, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Fuminori ItoTokiko Nakai
Jul 7, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Y WangY Cheng
Aug 21, 2019·Cancers·Rakesh KumarM Radhakrishna Pillai
Oct 21, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Carrie L RobinsonDavid L Kolin
Mar 20, 2021·The American Journal of Surgical Pathology·Natalie BanetAshley Cimino-Mathews

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