Clinicopathological and prognostic significance of programmed cell death ligand 1 expression in patients diagnosed with breast cancer: meta-analysis.

The British Journal of Surgery
M G DaveyM J Kerin

Abstract

Uncertainty exists regarding the clinical relevance of programmed cell death ligand 1 (PD-L1) expression in breast cancer. A systematic review was performed in accordance with PRISMA guidelines. Observational studies that compared high versus low expression of PD-L1 on breast cancer cells were identified. Log hazard ratios (HRs) for disease-free and overall survival and their standard errors were calculated from Kaplan-Meier curves or Cox regression analyses, and pooled using the inverse-variance method. Dichotomous variables were pooled as odds ratios (ORs) using the Mantel-Haenszel method. Sixty-five studies with 19 870 patients were included; 14 404 patients were classified as having low and 4975 high PD-L1 expression. High PD-L1 was associated with achieving a pathological complete response following neoadjuvant chemotherapy (OR 3.30, 95 per cent confidence interval 1.19 to 9.16; P < 0.01; I2 = 85 per cent). Low PD-L1 expression was associated with human epidermal growth factor receptor 2 (OR 3.98, 1.81 to 8.75; P < 0.001; I2 = 96 per cent) and luminal (OR 14.93, 6.46 to 34.51; P < 0.001; I2 = 99 per cent) breast cancer subtypes. Those with low PD-L1 had favourable overall survival rates (HR 1.30, 1.05 to 1.61; P = 0.02; I2...Continue Reading

References

Jun 29, 2004·Journal of Clinical Pathology·P J van DiestJ P A Baak
Apr 7, 2007·International Journal of Cancer. Journal International Du Cancer·Hazem GhebehSaid Dermime
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Feb 16, 2010·The Lancet Oncology·Rinat YerushalmiKaren A Gelmon
Jun 6, 2012·RNA Biology·Tony Gutschner, Sven Diederichs
Mar 22, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kurt A SchalperDavid L Rimm
Apr 26, 2014·Cancer Immunology Research·Elizabeth A MittendorfGheath Alatrash
May 21, 2014·Breast Cancer Research and Treatment·S MuenstS D Soysal
Sep 13, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R SalgadoUNKNOWN International TILs Working Group 2014
Feb 12, 2015·Oncotarget·Renaud SabatierFrançois Bertucci
May 16, 2015·Cancer Research·Michele W L TengMark J Smyth
Nov 7, 2015·Human Pathology·Mauricio Z BaptistaJosé Vassallo
May 3, 2016·F1000Research·Gustavo Baldassarre, Barbara Belletti
Jun 12, 2016·Journal of Translational Medicine·Woo Young SunJa Seung Koo
Oct 1, 2016·American Journal of Clinical Pathology·Xiaoxian LiRitu Aneja
Dec 8, 2016·International Journal of Cancer. Journal International Du Cancer·Sheng ChenZhi-Ming Shao
Mar 28, 2017·Oncology Research and Treatment·Florian SchützChristof Sohn
Apr 20, 2017·Applied Immunohistochemistry & Molecular Morphology : AIMM·Lauren E McLemoreSusan Fineberg
Jul 22, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Elizabeth D ThompsonAshley Cimino-Mathews
Oct 7, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Thomas A AdamsAgnieszka K Witkiewicz

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Citations

Aug 8, 2021·International Journal of Molecular Sciences·Matthew G DaveyMichael J Kerin
Aug 28, 2021·Journal of Clinical Medicine·Trishna SahaHava Gil-Henn
Oct 14, 2021·International Journal of Molecular Sciences·Matthew G DaveyMichael J Kerin

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