Clinicopathological changes and effect of imidocarb therapy in dogs experimentally infected with Babesia canis

Acta Veterinaria Hungarica
A MáthéL Tekes

Abstract

In this study one spleen-intact dog (A) and two splenectomised dogs (BSE, CSE) were infected with Babesia canis. All animals developed an acute disease characterised by fever, haemoglobinuria and anaemia, the latter being more severe in the splenectomised dogs. Fever and parasitised red blood cells were detected for three days after imidocarb treatment in the splenectomised animals. Haematological abnormalities included regenerative anaemia, thrombocytopenia and leukopenia (due to neutropenia and lymphopenia) in the acute phase, soon followed by leukocytosis, neutrophilia and left shift a few days later. Acute hepatopathy was detected in all dogs with elevated ALT activity, which was more seriously altered in the splenectomised dogs. Diffuse changes in liver structure and hepatomegaly were seen by ultrasonography. Liver biopsy and histology revealed acute, non-purulent hepatitis in the splenectomised dogs. Both splenectomised dogs were successfully cured after collection of 400 ml highly parasitised blood, proving that large-amount antigen production is possible with rescuing the experimental animals. Whole blood transfusion, imidocarb and supportive care with infusions, antipyretics, glucocorticoids and diuretics were applied....Continue Reading

References

Jun 1, 1991·Australian Veterinary Journal·P J Irwin, G W Hutchinson
Mar 31, 1998·The Veterinary Record·R CasapullaV Mizzoni
Feb 24, 2001·Journal of the South African Veterinary Association·A J MöhrJ J van der Lugt
Jun 29, 2001·International Journal for Parasitology·A M KjemtrupP A Conrad
Jul 27, 2001·The Veterinary Record·M L SuarezG Santamarina
Sep 21, 2001·Journal of the South African Veterinary Association·R G Lobetti, L S Jacobson
Feb 26, 2004·The Veterinary Record·R FarkasGy T Hegedüs
Feb 16, 2005·Veterinary Parasitology·Gábor FöldváriRóbert Farkas

❮ Previous
Next ❯

Citations

Mar 10, 2012·Parasites & Vectors·Viktor DyachenkoReinhard K Straubinger
Jan 5, 2016·Journal of Veterinary Internal Medicine·R M EichenbergerP Deplazes
Mar 17, 2010·Journal of Veterinary Emergency and Critical Care·Ashley L AyoobJennifer Prittie
Nov 15, 2011·Acta Veterinaria Hungarica·Zoltán DemeterSándor Hornok
Sep 8, 2007·Journal of the American Animal Hospital Association·Gina E PastoreVictoria Lipscomb

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Babesiosis (ASM)

Babesiosis is caused by parasites of the genus babesia, which are transmitted in nature by the bite of an infected tick. Discover the latest research on babesiosis here.

Babesiosis

Babesiosis is caused by parasites of the genus babesia, which are transmitted in nature by the bite of an infected tick. Discover the latest research on babesiosis here.