Clinicopathological changes at the vitreoretinal junction: posterior vitreous detachment

Eye
M P SneadA J Richards

Abstract

Separation of the vitreous and posterior hyaloid membrane (PHM) or posterior vitreous detachment (PVD) typically occurs between the ages of 45 and 65 years in the general population, but may occur earlier in myopic or otherwise predisposed individuals. Age-related synergetic changes occurring within the cortical and central gel must be distinguished from the PHM, which envelopes it. This study reports on the correlation between 'true' PVD seen clinically by the physician using dynamic examination, high-power slit-lamp biomicroscopy, and oblique illumination with some of its histological, immunohistochemical, and ultrastructural features post-mortem. The presence of the Weiss ring does not necessarily indicate total clean separation of PHM, nor does its absence confirm that the PHM remains attached, since it may be destroyed during the process of separation. Immediately prior to PVD with the vitreous gel attached, the PHM must, by definition, form part of the inner limiting membrane. The detached PHM frequently exhibits basement membrane (BM) and its indigenous laminocytes stain focally for GFAP and type IV collagen. The PHM is distinct from and much thicker than the BM of Müller cells alone and the factors that initiate or limi...Continue Reading

References

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Citations

Jun 29, 2011·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Courtney L KrausRajendra S Apte
Jan 21, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·N E Bechrakis, A Dimmer
Feb 25, 2009·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Rakhee ShahBruce J W Evans
Feb 6, 2017·International Ophthalmology·Eyyup KarahanSuleyman Kaynak
Mar 1, 2012·Retina·Andrzej Grzybowski, Efraín Romo-Garcia
Nov 24, 2019·Ophthalmology·Christina J FlaxelGui-Shuang Ying
Apr 27, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Mali OkadaJonathan Yeoh

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