Clinicopathological characteristics and outcomes in embryonal tumor with multilayered rosettes: A decade long experience from a tertiary care centre in North India.

Annals of Diagnostic Pathology
Kirti GuptaBishan Dass Radotra

Abstract

Embryonal tumor with multilayered rosettes (ETMR) are a heterogenous group clinically, pathologically and topographically. Due to limited cases, data regarding its molecular genetics, pathology and prognostic factors is evolving. We retrospectively analysed our cohort of ETMR over last decade in order to study their clinicopathological characteristics and outcome. Our cohort consisted of patients diagnosed with Embryonal tumor with abundant neuropil and true rosettes (ETANTR)/Ependymoblastoma (EBL)/ Medulloepithelioma (MEPL) over the past decade. Clinical details, including outcome and imaging data was retrieved. Histological analysis including immunohistochemical work-up was performed. Cohort included 15 patients with age range between 1 and 28 years and M:F ratio of 1.5:1. Supratentorial location predominated in comparison to tumors arising in posterior fossa. ETANTR and EBL patterns were equally distributed (40% each), followed by one case each of mixed pattern (EBL + ETANTR), MEPL and embryonal tumor, unclassified. All tumors readily expressed LIN 28A and INI-1 was retained. Recurrence with evidence of glial and rhabdoid differentiation was noted in a single patient 9 months following resection. Follow-up period ranged from...Continue Reading

References

Jul 13, 2000·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·C G EberhartP C Burger
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Oct 28, 2008·Molecular Cell·Inha HeoV Narry Kim
Nov 7, 2008·The American Journal of Surgical Pathology·Marco GessiCharles G Eberhart
May 26, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Belén Ferri NiguezJoaquín Sola
Jun 10, 2010·Acta Neuropathologica·Werner Paulus, Paul Kleihues
Mar 23, 2011·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Jeremy DeischDinesh Rakheja
Sep 17, 2013·Brain Pathology·Lucie Lafay-CousinJennifer A Chan
Feb 24, 2015·Virchows Archiv : an International Journal of Pathology·Manila AntonelliFelice Giangaspero
Oct 7, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Meryl HorwitzNicolas Andre
Mar 8, 2018·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Kirti GuptaPravin Salunke
May 26, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Bing WangLeena M Ketonen
Dec 6, 2019·Nature·Sander LamboMarcel Kool
Jul 1, 2020·Acta Neuropathologica·Sander LamboMarcel Kool

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