Clinicopathological characteristics and diagnostic performance of Wisteria floribunda agglutinin positive Mac-2-binding protein as a preoperative serum marker of liver fibrosis in hepatocellular carcinoma

Journal of Gastroenterology
Masato FujiyoshiHepatitis Glyco-biomarker Study Group

Abstract

Wisteria floribunda agglutinin positive Mac-2-binding protein (WFA(+)-M2BP) is a novel serum marker of liver fibrosis identified in glycoproteomic biomarker screening studies, and its clinicopathological characteristics have yet to be elucidated sufficiently for clinical utilization. We retrospectively analyzed the clinicopathology data and serum WFA(+)-M2BP levels in 376 hepatocellular carcinoma patients undergoing liver surgery. WFA(+)-M2BP was quantified in frozen serum samples collected at the time of surgery using the FastLec-Hepa method. Significant independent determinants of serum WFA(+)-M2BP levels included pathological diagnosis of cirrhosis, female gender, hepatitis C virus (HCV) infection, and liver dysfunction characteristics, such as abnormal indocyanine green retention rate at 15 min, platelet counts, albumin levels, alanine aminotransferase levels, and total bilirubin levels. Serum WFA(+)-M2BP levels increased with the pathological fibrosis stage and liver dysfunction severity. HCV infection significantly affected serum WFA(+)-M2BP levels throughout the pathological and functional progression of liver fibrosis, and the effect of gender was significant only in F4 stage patients with severe liver dysfunction. The ...Continue Reading

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Citations

Mar 1, 2016·Virusdisease·Nilotpal Banerjee, Sumi Mukhopadhyay
Sep 30, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroki NishikawaShuhei Nishiguchi
Sep 26, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroki NishikawaShuhei Nishiguchi
Jun 15, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Xia ZouXin-Xin Zhang
Mar 19, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Akio IshiiShuhei Nishiguchi
Dec 28, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jing-Jing YangJun Li
Feb 24, 2018·Journal of Gastroenterology and Hepatology·Yuji EsoHiroshi Seno
May 9, 2018·Journal of Gastroenterology and Hepatology·Haruki UojimaWasaburo Koizumi
May 8, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Natthaya ChuaypenPisit Tangkijvanich
Jul 25, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Norihiro IshiiKen Shirabe
Sep 5, 2019·Journal of Clinical Medicine·Hiroki NishikawaShuhei Nishiguchi
Dec 1, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Mitsuhisa TakatsukiSusumu Eguchi
Aug 25, 2020·Annals of Laboratory Medicine·Nobuharu TamakiNamiki Izumi
Jan 21, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroki NishikawaShuhei Nishiguchi
Feb 3, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroki NishikawaShuhei Nishiguchi
Apr 15, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroki NishikawaShuhei Nishiguchi
Aug 12, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Yusuke KimuraShinji Uemoto
Apr 14, 2017·Journal of Gastroenterology and Hepatology·Kiyoaki ItoMasashi Yoneda
Dec 23, 2016·Journal of Gastroenterology and Hepatology·Yuki BekkiYoshihiko Maehara

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