Clinicopathological characteristics, practical treatments, prognosis, and clinical issues of older breast cancer patients in Japan.

Breast Cancer : the Journal of the Japanese Breast Cancer Society
Masataka SawakiShigehira Saji

Abstract

Minimal data are available to support the clinical management of older breast cancer patients. Consequently, the standard of care remains unclear. Our aim was to clarify the clinicopathological characteristics, practical treatments, and prognosis of older Japanese breast cancer patients and discuss clinical issues. We reviewed 132,240 cases, diagnosed between 2004 and 2011, from the Japanese Breast Cancer Registry. Focusing on older patients, we compared data among three age groups: 75 years and over (n = 27,385), 65-74 years (n = 43,839), and 55-64 years (n = 61,016). Data revealed the proportions of mucinous and apocrine carcinoma were higher in older patients, and they more frequently had clinical stage II and III cancer. Their ER-positive rates were higher, in contrast to the lower HER2-positive, breast-conserving surgery (BCS), post-BCS irradiation, and adjuvant chemotherapy rates. Almost half of the older patients who underwent chemotherapy received CMF or oral 5FU, during hormone therapy, Tamoxifen was administered more frequently. The overall survival rate decreased with age, but the breast cancer-specific survival (BCSS) at 5 years remained similar. The rate of other cause of death in the oldest group was about a half,...Continue Reading

References

Dec 7, 1994·Journal of the National Cancer Institute·S B YellenW T Leslie
Apr 5, 2002·The New England Journal of Medicine·Terri R FriedHeather Allore
Sep 3, 2004·The New England Journal of Medicine·Kevin S HughesUNKNOWN Eastern Cooperative Oncology Group
Dec 17, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·M W R ReedL Wyld
Sep 17, 2009·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Naruto TairaYasuo Ohashi
Nov 19, 2009·Annals of Internal Medicine·Heidi D NelsonUNKNOWN U.S. Preventive Services Task Force
Feb 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alice B KornblithHyman B Muss
Aug 4, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arti HurriaWilliam P Tew
Jan 8, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C KenisH Wildiers
Feb 19, 2013·Journal of the American Medical Directors Association·Masahiro AkishitaKenji Toba
May 22, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kevin S HughesWilliam C Wood
Jul 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arti HurriaUNKNOWN American Society of Clinical Oncology
Oct 27, 2015·JAMA : the Journal of the American Medical Association·Kevin C OeffingerUNKNOWN American Cancer Society
May 18, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arti HurriaWilliam P Tew
May 22, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Supriya G MohileArti Hurria
May 13, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Makoto KuboHiromitsu Jinno

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Citations

Jul 23, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Akimitsu YamadaMasataka Sawaki

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