Abstract
The Akt/mammalian target of rapamycin (mTOR) pathway is up-regulated in many human cancers, and agents targeting the mTOR pathway are in various stages of clinical development and application. Expression of pAkt and mTOR was studied by immunohistochemical analysis of 574 surgically resected non-small cell lung cancer (NSCLC) specimens on a tissue microarray. The results were correlated with clinicopathological features. Expression of mTOR showed a strong correlation with the expression of pAkt (p < 0.001) and was significantly associated with female gender, tumor size of ≤3 cm, adenocarcinoma (ADC), non-smoker status, and lower pathological stage. Expression of pAkt was correlated with older age (≥65), ADC, non-smoker status, and lower T stage. Univariate survival analysis revealed that the mTOR- and pAkt-positive group had a significantly longer cancer-specific survival than the mTOR- and pAkt-negative group (p = 0.038 and 0.024, respectively). Coexpression of pAkt and mTOR correlated with better prognosis than either single- or double-negative pAkt and mTOR groups (p = 0.016). However, multivariate analysis proved that mTOR and pAkt expression are not independent prognostic factors for cancer-specific survival. Expression of ...Continue Reading
References
May 24, 2000·Oncogene·Z Q YuanJ Q Cheng
Aug 4, 2001·The American Journal of Pathology·M SunJ Q Cheng
Jan 18, 2003·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Kip A WestPhillip A Dennis
Jan 23, 2004·Journal of Cellular Biochemistry·Deborah A AltomareJoseph R Testa
Jul 9, 2004·Carcinogenesis·Binaifer R BalsaraJoseph R Testa
Aug 20, 2004·American Journal of Respiratory and Critical Care Medicine·Pierre P MassionAdriana L Gonzalez
Sep 15, 2004·British Journal of Cancer·S Chan
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Odile DavidArnold R Brody
Sep 2, 2006·The Lancet Oncology·Jean-Yves DouillardPatrick Hurteloup
Jan 24, 2007·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Mar 6, 2007·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Daiki MurakamiMasahide Ikeguchi
Mar 14, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tomoshi TsuchiyaNaoya Yamasaki
Apr 5, 2007·The Oncologist·Heather WakeleeDavid Gandara
Apr 19, 2007·Cancer·Allan J PantuckRobert A Figlin
Jan 2, 2008·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jaclyn LoPiccoloPhillip A Dennis
Apr 5, 2008·Cancer·Argun AkcakanatFunda Meric-Bernstam
Feb 4, 2009·Histopathology·William D Travis, UNKNOWN IASLC Staging Committee
May 1, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Olga C J SchuurbiersJohan Bussink
Jun 3, 2009·Medical Oncology·Xin WangJie Wang
Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Valsamo K AnagnostouDavid L Rimm
Jan 23, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tony DhillonMichael J Seckl
Feb 17, 2010·Journal of Cancer Research and Clinical Oncology·Pei YuKe Li
Citations
May 22, 2013·PloS One·Daisuke IshikawaSeiji Yano
Apr 30, 2014·PloS One·Alberto OcanaEitan Amir
Feb 3, 2016·Nature Communications·Susana LlanosManuel Serrano
May 6, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Eun ShinYoung Soo Park
Nov 19, 2013·Urologic Oncology·Masatomo NishikawaMasato Fujisawa
Mar 25, 2014·Human Pathology·Adriana Handra-Luca
Dec 17, 2016·Journal of Clinical Pathology·Si-Hyong JangMee-Hye Oh
Feb 6, 2020·PloS One·Junmi LuSongqing Fan
Feb 6, 2020·Pathology Oncology Research : POR·Ildiko KrenczAndras Khoor
Jun 4, 2013·Oncology Reports·Eleni Andriana TrigkaPenelope Korkolopoulou
Aug 10, 2017·Oncology Letters·Zixuan Zhang, Mengzhao Wang
Dec 25, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kathryn A GoldWaun K Hong
Apr 19, 2021·BMC Medical Imaging·Bingqian ZhangMinming Zhang