Clinicopathological factors associated with BRAF-V600E mutation in colorectal serrated adenomas

Histopathology
Antonio TravaglinoMaria D'Armiento

Abstract

Serrated adenomas are genetically heterogeneous, and the histological classification into sessile serrated (SSA) adenoma and traditional serrated adenoma (TSA) does not reflect the molecular landscape. The objective of this study was to assess clinical or pathological factors associated with BRAF-V600E mutation in serrated adenomas. Systematic review and meta-analysis was performed by searching electronic databases from January 2011 to January 2019 for studies assessing the association of BRAF-V600E mutation with clinical or pathological features of serrated adenomas. Odds ratio (OR) was calculated for each factor; a P-value <0.05 was considered significant. Forty studies assessing 3511 serrated adenomas (2375 SSAs and 1136 TSAs) were included. BRAF-V600E mutation was significantly associated with proximal localisation (OR = 2.71; P < 0.00001) and CIMP-H status (OR = 4.81; P < 0.0001) in both SSA and TSA, with polyp size <10 mm (OR = 0.41; P = 0.02) in TSA, and with endoscopic pit pattern II-O (OR = 13.11; P < 0.00001) and expression of MUC5A5 (OR = 4.43; P = 0.003) and MUC6 (OR = 2.28; P < 0.05) in SSA. Conversely, BRAF mutation was not associated with age <70 years (OR = 1.63; P = 0.34), age <60 years (OR = 0.86; P = 0.79), f...Continue Reading

References

Jul 1, 1996·Gastrointestinal Endoscopy·S KudoH Watanabe
Jun 21, 2008·World Journal of Gastroenterology : WJG·Hugh-James Freeman
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Jan 26, 2011·The American Journal of Surgical Pathology·Kohei FujitaYoshinao Oda
Mar 24, 2011·The American Journal of Gastroenterology·Yuichiro YanoMichio Imawari
Aug 13, 2011·The American Journal of Surgical Pathology·Kyoung-Mee KimRobert Daniel Odze
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Jan 12, 2012·The American Journal of Gastroenterology·Tomoaki KimuraMinoru Toyota
Mar 6, 2012·The American Journal of Gastroenterology·Carol A Burke, Dale C Snover
Apr 19, 2012·The American Journal of Surgical Pathology·Christophe RostyJoanne P Young
Jun 20, 2012·The American Journal of Gastroenterology·Douglas K RexJames Church
Aug 23, 2012·American Journal of Clinical Pathology·Baojin FuChristine A Iacobuzio-Donahue
Oct 12, 2012·Virchows Archiv : an International Journal of Pathology·Arzu EnsariFred Bosman
Jun 29, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Michael D WalshDaniel D Buchanan
Jul 28, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ildiko MesteriPeter Birner
Oct 12, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C ClancyJ C Coffey
May 9, 2014·Gastroenterology Research and Practice·Winnie C FernandoKevin J Spring
Jun 14, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Takashi MurakamiSumio Watanabe
Aug 12, 2014·World Journal of Gastroenterology : WJG·Takafumi NaitoYasuhisa Shinomura
Sep 13, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mark L BettingtonVicki Lj Whitehall
Jan 7, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kenneth P Batts
May 24, 2015·Human Pathology·Mark L Bettington, Runjan Chetty
Oct 18, 2015·International Journal of Cancer. Journal International Du Cancer·Florence RenaudMarie-Pierre Buisine
Mar 1, 2016·The Journal of Pathology·Shigeki SekineAtsushi Ochiai
Apr 22, 2017·American Journal of Clinical Pathology·Magomed KhaidakovCurt H Hagedorn
Jun 15, 2017·The American Journal of Surgical Pathology·Taiki HashimotoNobuyoshi Hiraoka

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Citations

Jul 25, 2019·Cancers·Fatima Domenica Elisa De PalmaFrancesco Salvatore
Dec 4, 2020·World Journal of Gastroenterology : WJG·Milena PeruhovaTsvetelina Veselinova Velikova

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