Clinicopathological factors associated with HER2-positive gastric cancer: A meta-analysis

Medicine
Hong-Bo WangJian Zhang

Abstract

The treatment of patients with advanced gastric cancer remains a most challenging task in the clinical practice. Recently, targeted therapies have significantly impacted the treatment strategy for many common malignancies. The use of trastuzumab, a monoclonal antibody against human epidermal growth factor receptor 2 (HER2; also known as ERBB2), plus chemotherapy proved to improve median overall survival in patients with advanced gastric cancer, compared with chemotherapy alone in Trastuzumab for Gastric Cancer (ToGA) trial. However, the prognostic value of HER2 status in gastric cancer remains controversial. Therefore, the aim of this study was to investigate the clinical pathology significance of HER2 overexpression in resectable gastric cancer for selecting the right patients with gastric cancer who may benefit from trastuzumab treatment. Publications reported the clinicopathological factors associated with HER2 status in gastric cancer from 2012 to 2017 were collected. The literature databases, such as "Cochrane Library", "Sciencedirect", "Springer", "PubMed", "Embase", were extensively searched to retrieve the clinical studies of HER2 expression in gastric cancer. The major outcomes measures were odds ratios (ORs) and their...Continue Reading

References

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Citations

Apr 22, 2018·Bioscience Reports·Saroj ThapaKangting Ji
Oct 9, 2019·Molecular Diagnosis & Therapy·Marina Alessandra PereiraEvandro Sobroza de Mello
Jun 10, 2020·International Journal of Molecular Sciences·Julita MachlowskaRobert Sitarz
Sep 26, 2020·Journal of Clinical Medicine·Valentina GambardellaAndrés Cervantes
Jul 11, 2018·World Journal of Gastrointestinal Oncology·Dai ShimizuYasuhiro Kodera
Feb 13, 2019·British Journal of Cancer·Lorenzo FornaroFrancesco Montagnani
Dec 18, 2020·Frontiers in Oncology·Astrid E SlagterMarcel Verheij
Mar 1, 2021·Cancer Chemotherapy and Pharmacology·Daisuke MatsushitaShoji Natsugoe
Apr 10, 2018·Cancer Treatment Reviews·Madiha NaseemHeinz-Josef Lenz
May 3, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V GambardellaA Cervantes
Aug 26, 2021·The Korean Journal of Internal Medicine·Seonhoo KimWoo Chul Chung
Dec 10, 2021·Personalized Medicine·Khalil El GharibHampig Raphael Kourie

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