Clinicopathological factors predictive of postoperative seizures in patients with gliomas

Seizure : the Journal of the British Epilepsy Association
Pei YangTao Jiang

Abstract

Epilepsy is one of the most common manifestations in gliomas and has a severe effect on the life expectancy and quality of life of patients. The aim of our study was to assess the potential connections between clinicopathological factors and postoperative seizure. We retrospectively investigated a group of 147 Chinese high-grade glioma (HGG) patients with preoperative seizure to examine the correlation between postoperative seizure and clinicopathological factors and prognosis. Univariate analyses and multivariate logistic regression analyses were performed to identify factors associated with postoperative seizures. Survival function curves were calculated using the Kaplan-Meier method. 53 patients (36%) were completely seizure-free (Engel class I), and 94 (64%) experienced a postoperative seizure (Engel classes II, III, and IV). A Chi-squared analysis showed that anaplastic oligodendroglioma/anaplastic oligoastrocytoma (AO/AOA) (P=0.05), epidermal growth factor receptor (EGFR) expression (P=0.0004), O(6)-methylguanine DNA methyltransferase (MGMT) expression (P=0.011), and phosphatase and tensin homolog (PTEN) expression (P=0.045) were all significantly different. A logistic regression analysis showed that MGMT expression (P=0....Continue Reading

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Citations

Sep 27, 2016·Epilepsia·Andrew NealPatrick Kwan
Jul 29, 2017·Journal of Neurosurgery·Soliman OushyD Ryan Ormond
Oct 10, 2018·Clinical Nuclear Medicine·Jingnan WangRuixue Cui
Aug 28, 2018·Chinese Neurosurgical Journal·Tingyu LiangGan You
Jul 6, 2016·Journal of Neuro-oncology·Kristin M Knudsen-BaasJone F Owe
Sep 10, 2020·Progress in Neurobiology·Ning AnBart P F Rutten
Feb 2, 2021·Frontiers in Oncology·Gan YouTao Jiang
Feb 1, 2021·Neurosurgery·Philip C De Witt HamerMitchel S Berger
Aug 31, 2021·Frontiers in Cell and Developmental Biology·Xingang ZhouPeng Wang
Nov 19, 2021·Journal of Neurological Surgery. Part A, Central European Neurosurgery·Alessandro PesceAntonio Santoro

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