PMID: 30157363Aug 30, 2018Paper

Clinicopathological features and management of penile verrucous carcinoma

Zhonghua nan ke xue = National journal of andrology
Guo-Xiao ChenXin Chen

Abstract

To explore the clinicopathological characteristics, diagnosis and treatment of penile verrucous carcinoma (VC). We retrospectively analyzed the clinical data about 18 penile VC patients at the mean age of 52 (35-66) years. The tumors were cauliflower-like, measuring 2.5-8.7 cm in diameter, all with mucopurulentive discharge. A giant tumor invaded the perineum in 1 case, which had a history of surgical excision of penile condyloma acuminatum. The lesions invaded the glans penis in 2 cases, the shafts in 4 (all with a history of phimosis or redundant prepuce), and the whole penis in 11. Partial penectomy was performed for 2 cases with the proximal coronary sulcus involved and another 2 with the condylomata located in the glans penis and measuring <3.5 cm in diameter. Radical surgery was done for 2 cases of glans VC >3.5 cm in diameter, 11 cases with the whole penis involved, and 1 case with the perineum invaded. Postoperative pathology showed well-differentiated tumor cells, negative surgical margins, papillary epithelia with hyperkeratosis and hyperplasia, and lymphocyte infiltration in the surrounding interstitial tissue in all the cases. Neither recurrence nor metastasis was found during the 1 to 8 years of follow-up. Penile V...Continue Reading

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