Clinicopathological features and oncological outcomes of patients with young-onset rectal cancer.

The British Journal of Surgery
A ZaborowskiD C Winter

Abstract

The incidence of rectal cancer among adults aged less than 50 years is rising. Survival data are limited and conflicting, and the oncological benefit of standard neoadjuvant and adjuvant therapies is unclear. Disease-specific outcomes of patients diagnosed with rectal cancer undergoing surgical resection with curative intent between 2006 and 2016 were analysed. A total of 797 patients with rectal cancer were identified, of whom 685 had surgery with curative intent. Seventy patients were younger than 50 years and 615 were aged 50 years or more. Clinical stage did not differ between the two age groups. Patients aged less than 50 years were more likely to have microsatellite instability (9 versus 1·6 per cent; P = 0·003) and Lynch syndrome (7 versus 0 per cent; P < 0·001). Younger patients were also more likely to receive neoadjuvant chemoradiotherapy (67 versus 53·3 per cent; P = 0·003) and adjuvant chemotherapy (41 versus 24·2 per cent; P = 0·006). Five-year overall survival was better in those under 50 years old (80 versus 72 per cent; P = 0·013). The 5-year disease-free survival rate was 81 per cent in both age groups (P = 0·711). There were no significant differences in the development of locoregional recurrence or distant me...Continue Reading

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Citations

Mar 19, 2020·The British Journal of Surgery·Q Denost
Apr 28, 2020·The British Journal of Surgery·G Pellino
May 20, 2020·The British Journal of Surgery·J PereaUNKNOWN on behalf of the Spanish EOCRC group and the European study of EOCRC group (EUREOC)
Jun 17, 2020·The British Journal of Surgery·G Pellino Editor Assistant
Oct 27, 2020·The British Journal of Surgery·B R J Healey Bird
Mar 13, 2021·The British Journal of Surgery·C A FlemingC B Peirce
Nov 4, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Antonio V SterpettiPaolo Sapienza
Jul 1, 2021·JAMA Surgery·UNKNOWN REACCT CollaborativeDes C Winter
Aug 12, 2021·The British Journal of Surgery·G L Beets
Nov 6, 2021·The British Journal of Surgery·Renu R BahadoerUNKNOWN International Watch & Wait Database Consortium (IWWD)

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