Clinicopathological Features and Prognosis of Primary GISTs with Tumor Rupture in the Real World

Annals of Surgical Oncology
Toshirou NishidaKinki GIST Study Group

Abstract

Patients with ruptured gastrointestinal stromal tumor (GIST) are recommended for imatinib adjuvant therapy; however, their clinicopathological features and prognosis in the era of imatinib are unknown. The study cohort included 665 patients with histologically proven primary GISTs who underwent R0 or R1 surgery between 2003 and 2007; the validation cohort included 182 patients between 2000 and 2014. The definitions of tumor rupture in the study included perforation at tumor site, tumor fracture, piecemeal resection including open biopsy, and macroscopic injuries to the pseudocapsule. Tumor rupture occurred in 21 (3.2%) of 665 and 5 (2.9%) of 182 patients in the study and validation cohort, respectively. Ruptured GISTs were more symptomatic, were larger in size, and had higher mitotic count than nonruptured GISTs but were not associated with tumor location or laparoscopic surgery. GISTs with intraoperative rupture had clinicopathological features and prognostic outcomes similar to those with preoperative rupture. Recurrence rates were higher and median recurrence-free survival (RFS) and overall survival (OS) were shorter with ruptured than nonruptured GIST. Tumor rupture was one of the independent prognostic factors for RFS, but...Continue Reading

References

Dec 30, 2006·Seminars in Diagnostic Pathology·Markku Miettinen, Jerzy Lasota
Oct 12, 2007·International Journal of Clinical Oncology·Tsuyoshi TakahashiToshirou Nishida
Aug 24, 2010·The British Journal of Surgery·P HohenbergerP Reichardt
Nov 10, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marion VerduijnSaskia le Cessie
Jul 9, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P RutkowskiH Joensuu
Mar 29, 2012·JAMA : the Journal of the American Medical Association·Heikki JoensuuPeter Reichardt
Apr 30, 2013·Lancet·Heikki JoensuuChristopher L Corless
Jul 19, 2013·Annals of Surgery·Ronald P DeMatteoUNKNOWN American College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study Team for the Alliance for Clinical Trial
May 24, 2014·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yoshitomo YanagimotoToshirou Nishida
Sep 24, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Danielle A BischofTimothy M Pawlik
Aug 16, 2015·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Toshirou NishidaYoon-Koo Kang

❮ Previous
Next ❯

Citations

Apr 2, 2019·Cancer·Mark S Etherington, Ronald P DeMatteo
Feb 29, 2020·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Jian WangHongjie Hu
Aug 10, 2019·Annals of Surgical Oncology·Toshirou Nishida, Piotr Rutkowski
Mar 25, 2019·Annals of Surgical Oncology·E A Asare, B W Feig
Mar 15, 2019·Annals of Surgical Oncology·Toshirou NishidaPiotr Rutkowski
Dec 1, 2018·Visceral Medicine·Jens Jakob, Peter Hohenberger
Nov 14, 2018·Annals of Surgical Oncology·Toshirou Nishida
Feb 13, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Meng KongLeping Li
Apr 14, 2020·International Journal of Surgery Case Reports·Ryosuke ArataTakashi Nishisaka
Feb 27, 2021·International Journal of Cancer. Journal International Du Cancer·Kathryn E MarqueenCelina Ang
Jul 4, 2020·Translational Oncology·Haixin Zhang, Qi Liu
Jul 30, 2021·Technology in Cancer Research & Treatment·Xin FanJixiang Chen

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
surgical resection

Software Mentioned

SPSS Statistics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.