Clinicopathological features of five unusual cases of intraosseous myoepithelial carcinomas, mimicking conventional primary bone tumours, including EWSR1 rearrangement in one case

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Bharat RekhiAjay Puri

Abstract

Primary intraosseous myoepithelial tumours, including carcinomas are rare tumours. The concept of histopathological spectrum of these tumours is evolving. We describe clinicopathological and immunohistochemical features of five myoepithelial carcinomas, including molecular cytogenetic results in one case. There were five male patients within age-range of 8-40 years (median = 26). Four tumours occurred in the long bones, including two tumours, each, in the femur and fibula, respectively, while a single tumour occurred in the proximal phalanges. Tumour size (n = 3 cases) varied from 5.6 to 8.6 cm. On radiological imaging, most tumours appeared as expansile, lytic and destructive lesions. Two tumours appeared as sclerotic lesions. Two cases were referred with diagnoses of chondrosarcomas and a single case was referred with two different diagnoses, including an adamantinoma and an osteosarcoma. Histopathological examination in all these cases showed multinodular tumours comprising mostly polygonal cells, exhibiting moderate nuclear atypia and interspersed mitotic figures within a stroma containing variable amount of myxoid, chondroid, hyalinised and osteoid-like material. Three tumours revealed prominent squamous differentiation. B...Continue Reading

References

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May 17, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M AlberghiniF Bertoni
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May 18, 2013·The American Journal of Surgical Pathology·Pawel KurzawaG Petur Nielsen
Jun 20, 2014·Indian Journal of Pathology & Microbiology·Bharat RekhiNirmala A Jambhekar
Feb 24, 2015·Genes, Chromosomes & Cancer·Shih-Chiang HuangCristina R Antonescu

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Citations

Jul 26, 2018·International Journal of Surgical Pathology·Bharat RekhiAjay Puri
Jun 25, 2019·Frontiers in Neurology·Phillip E VlisidesPaul Picton
Oct 30, 2020·Cancers·Emanuela PalmeriniEric L Staals

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