Clinicopathological features of inflammatory pseudotumour-like follicular dendritic cell tumour of the abdomen

Histopathology
Yanyang ChenAnjia Han

Abstract

Inflammatory pseudotumour-like follicular dendritic cell (FDC) tumour is an extremely rare neoplasm. Herein, we report 10 cases of inflammatory pseudotumour-like FDC tumours in the abdomen and analyse their clinicopathological features. Seven patients were male, and three patients were female. The patients' age ranged from 28 years to 68 years (mean age, 52.9 years; median age, 51.5 years). Grossly, the tumour was usually solitary, well circumscribed, and solid, ranging from 23 mm to 233 mm in greatest diameter. Microscopically, the tumour was composed of variable amounts of spindle tumour cells with intense lymphoplasmacytic infiltrate. Unusual morphological findings, including eosinophils focally aggregated in one tumour admixed with multinucleated histiocytes in small clusters, fibrinoid deposits in the walls of ectatic blood vessel with occasional perivascular cuffs of lymphocytes, hyalinized fibrosis, and epithelioid granuloma, were identified. The tumour cells were immunoreactive for CD21, CD23, CD35, smooth muscle actin, and Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (7/10, 70%). EBV-encoded small RNA was positive in all cases by in situ hybridization. The recurrence rate was 10% with a median follow-up o...Continue Reading

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Citations

Jun 20, 2016·Seminars in Diagnostic Pathology·Fabio Facchetti, Luisa Lorenzi
Apr 28, 2017·Archives of Pathology & Laboratory Medicine·Chris Van Baeten, Jo Van Dorpe
Jan 8, 2020·World Journal of Gastrointestinal Oncology·Bi-Xi ZhangYan-Chun Li
Jul 1, 2020·Seminars in Diagnostic Pathology·Valentina Fabiola Ilenia Sangiorgio, Daniel A Arber
Oct 6, 2020·Seminars in Diagnostic Pathology·Sonam PrakashWayne Tam
Apr 23, 2020·Archives of Pathology & Laboratory Medicine·Zainab I Alruwaii, Elizabeth A Montgomery
Jul 30, 2021·Journal of Medical Case Reports·Ana Daniela PascariuCezar Iulian Bețianu
Nov 28, 2021·Pathologica·Fabio FacchettiLuisa Lorenzi

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