Clinicopathological features of recurrence after radical cystectomy for patients with transitional cell carcinoma of the bladder

International Urology and Nephrology
Ken-ichi HaradaHideaki Miyake

Abstract

The objective of this study was to investigate the clinicopathological features of recurrent transitional cell carcinoma (TCC) of the bladder in patients who had previously undergone radical cystectomy. This study included 124 patients who underwent radical cystectomy for transitional cell carcinoma (TCC) of the bladder in our institution. Several clinicopathological factors were analyzed to characterize differences between patients with and without disease recurrence, and determined predictive factors for disease recurrence using multivariate analysis. We further analyzed prognostic parameters that affect survival after disease recurrence was diagnosed. Of the 124 patients, 24 (19.5%) developed recurrence, and the median time to recurrence was 9.5 months (range, 1-44 months). The 5-year recurrence-free survival in these 124 patients was 75.6%. The incidence of disease recurrence was significantly associated with gender, pathological stage, lymph node metastasis, lymphatic invasion and blood vessel invasion. Multivariate analysis identified gender, pathological stage and lymph node metastasis as independent predictors of disease recurrence following radical cystectomy. After disease recurrence, the 1-year cancer-specific surviv...Continue Reading

References

Feb 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P SteinD G Skinner
Mar 21, 2001·The Journal of Urology·G DalbagniV Reuter
Oct 9, 2003·The Journal of Urology·Badrinath R Konety, Sue A Joslyn
Jun 18, 2004·The Journal of Urology·Mohamed Abdel-LatifMohamed A Ghoneim

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