Abstract
The aim of the study was to clarify clinicopathological features of type 2 autoimmune pancreatitis (AIP) in Japan; a multicenter survey was carried out. The first screening collected patients with pancreatitis whose pancreatic tissue samples were available and who fulfilled at least 1 of the following 3 criteria as possible type 2 AIP: (1) histological presence of granulocytic epithelial lesion, (2) age of 50 years or younger, and (3) association of ulcerative colitis, Sjogren syndrome, and/or primary biliary cirrhosis. Patients with histologically confirmed type 1 AIP were also collected as a control. Clinical information was gathered by questionnaire. A histological re-evaluation identified 8 patients with type 2 AIP and 20 with type 1 AIP. Three of the latter had intralobular neutrophilic infiltration. Factors more frequent in type 2 included age younger than 40 years, abdominal pain, and elevation of serum amylase and lipase, whereas patients with type 1 more frequently showed jaundice, elevated serum IgG and IgG4, presence of autoantibodies, association of IgG4-related disease, sclerosing cholangitis and diabetes mellitus, and imaging findings of intrapancreatic biliary stenosis and extrapancreatic biliary dilatation. The ...Continue Reading
References
Apr 1, 1991·Human Pathology·K KawaguchiN Fujita
Jul 1, 1995·Digestive Diseases and Sciences·K YoshidaN Hayashi
Mar 10, 2001·The New England Journal of Medicine·H HamanoK Kiyosawa
Apr 30, 2002·Lancet·Hideaki HamanoKendo Kiyosawa
Apr 15, 2003·Gut·T KamisawaH Nakajima
Jul 29, 2003·The American Journal of Surgical Pathology·Kenji NotoharaThomas C Smyrk
Nov 14, 2003·Journal of Gastroenterology·Terumi KamisawaHitoshi Nakajima
Nov 2, 2004·Virchows Archiv : an International Journal of Pathology·Giuseppe ZamboniGünter Klöppel
Aug 26, 2006·Journal of Gastroenterology·Kazuichi OkazakiUNKNOWN Research Committee of Intractable Diseases of the Pancreas
Sep 19, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lizhi ZhangThomas C Smyrk
Feb 9, 2007·Journal of Gastroenterology·Hideaki HamanoShigeyuki Kawa
Apr 1, 2010·Gastroenterology·Raghuwansh P SahSanthi S Vege
Jun 22, 2010·Pancreas·Suresh T ChariUNKNOWN Autoimmune Pancreatitis International Cooperative Study Group (APICS)
Dec 18, 2010·The American Journal of Surgical Pathology·Vikram DeshpandeGregory Y Lauwers
Mar 18, 2011·Pancreas·Tooru ShimosegawaUNKNOWN International Association of Pancreatology
Jul 13, 2011·Pancreas·Terumi KamisawaVay Liang W Go
Sep 21, 2011·Journal of Gastroenterology and Hepatology·Tae Jun SongEunsil Yu
May 19, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Vikram DeshpandeJohn H Stone
Jun 13, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Sönke DetlefsenGünter Klöppel
Jun 28, 2012·Arthritis and Rheumatism·John H StoneSuresh Chari
Citations
Nov 23, 2017·PloS One·Masaki MiyazawaShuichi Kaneko
Oct 21, 2017·Journal of Investigative Medicine High Impact Case Reports·Chidinma OnweniMark F Young
Mar 13, 2018·Internal Medicine·Yoon Suk LeeJune Sung Lee
Apr 12, 2019·Gut and Liver·Dongwook OhMyung-Hwan Kim
Sep 12, 2020·World Journal of Clinical Cases·Mario Pelaez-LunaLuis Uscanga-Domínguez
Jun 20, 2020·United European Gastroenterology Journal·J-Matthias LöhrUNKNOWN UEG guideline working group
Apr 15, 2020·Minerva gastroenterologica e dietologica·Davide G Ribaldone
Aug 9, 2020·Pathology International·Kenji NotoharaKazuichi Okazaki
Jul 20, 2021·Autoimmunity Reviews·Ammar QureshiKam A Newman