Clinicopathological Features of Type 2 Autoimmune Pancreatitis in Japan: Results of a Multicenter Survey

Pancreas
Kenji NotoharaTooru Shimosegawa

Abstract

The aim of the study was to clarify clinicopathological features of type 2 autoimmune pancreatitis (AIP) in Japan; a multicenter survey was carried out. The first screening collected patients with pancreatitis whose pancreatic tissue samples were available and who fulfilled at least 1 of the following 3 criteria as possible type 2 AIP: (1) histological presence of granulocytic epithelial lesion, (2) age of 50 years or younger, and (3) association of ulcerative colitis, Sjogren syndrome, and/or primary biliary cirrhosis. Patients with histologically confirmed type 1 AIP were also collected as a control. Clinical information was gathered by questionnaire. A histological re-evaluation identified 8 patients with type 2 AIP and 20 with type 1 AIP. Three of the latter had intralobular neutrophilic infiltration. Factors more frequent in type 2 included age younger than 40 years, abdominal pain, and elevation of serum amylase and lipase, whereas patients with type 1 more frequently showed jaundice, elevated serum IgG and IgG4, presence of autoantibodies, association of IgG4-related disease, sclerosing cholangitis and diabetes mellitus, and imaging findings of intrapancreatic biliary stenosis and extrapancreatic biliary dilatation. The ...Continue Reading

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Citations

Oct 21, 2017·Journal of Investigative Medicine High Impact Case Reports·Chidinma OnweniMark F Young
Mar 13, 2018·Internal Medicine·Yoon Suk LeeJune Sung Lee
Sep 12, 2020·World Journal of Clinical Cases·Mario Pelaez-LunaLuis Uscanga-Domínguez
Jun 20, 2020·United European Gastroenterology Journal·J-Matthias LöhrUNKNOWN UEG guideline working group
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Aug 9, 2020·Pathology International·Kenji NotoharaKazuichi Okazaki
Jul 20, 2021·Autoimmunity Reviews·Ammar QureshiKam A Newman

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