Clinicopathological impact of ABCC1/MRP1 and ABCC4/MRP4 in epithelial ovarian carcinoma

BioMed Research International
Marina BagnoliPaola Perego

Abstract

Ovarian cancer is the main cause of death from gynaecological malignancies. In spite of the efficacy of platinum-paclitaxel treatment in patients with primary epithelial ovarian carcinoma, platinum-based chemotherapy is not curative and resistance remains one of the most important causes of treatment failure. Although ABC transporters have been implicated in cellular resistance to multiple drugs, the clinical relevance of these efflux pumps is still poorly understood. Thus, we examined the prognostic role of transporters of the MRP family (i.e., ABCC1/MRP1, ABCC4/MRP4) to gain insights into their clinical impacts. A case material of 127 patients with ovarian carcinoma at different stages and histotypes was used. The expression of MRP1 and MRP4 was examined by immunohistochemistry using tissue microarrays in tumor specimens collected at the time of initial surgery expression. We found an association between MRP1 expression and grading, and we observed that MRP4 displayed an unfavourable impact on disease relapse in multivariate analysis (HR = 2.05, 95% CI: 1.01-4.11; P = 0.045). These results suggest that in epithelial ovarian cancer, MRP1 may be a marker for aggressiveness because its expression was associated with tumor grade ...Continue Reading

References

Jan 1, 1981·Cancer·A B MillerA Winkler
Aug 17, 2000·Journal of the National Cancer Institute·P BorstJ Wijnholds
Mar 21, 2002·Nature Reviews. Cancer·Michael M GottesmanSusan E Bates
Aug 21, 2003·Gynecologic Oncology·Michael L Berman
Oct 8, 2003·The Oncologist·Gregory D LeonardSusan E Bates
Apr 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michelle HaberMurray D Norris
Jun 29, 2006·International Journal of Cancer. Journal International Du Cancer·Daniela AldoviniMattia Barbareschi
Oct 31, 2006·Omics : a Journal of Integrative Biology·Adriana Aguilar-MahechaMark Basik
Jun 19, 2007·Biochimica Et Biophysica Acta·Jean-Pierre GilletJosé Remacle
Dec 6, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Sara Vander BorghtTania Roskams
May 23, 2009·Nature Reviews. Cancer·Robert C BastGordon B Mills
Aug 20, 2009·Mini Reviews in Medicinal Chemistry·L GattiP Perego
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Giulia BertoliniGabriella Sozzi
Dec 17, 2009·Biochemical Pharmacology·Giovanni Luca BerettaPaola Perego
Dec 18, 2009·Expert Review of Anticancer Therapy·Philipp HarterAndreas du Bois
Jan 9, 2010·Gynecologic Oncology·Valentina GuarneriPier Franco Conte
Jan 16, 2010·Nature Reviews. Cancer·Jamie I FletcherMurray D Norris
Sep 24, 2011·Nature Reviews. Cancer·Sebastian VaughanFrances R Balkwill

❮ Previous
Next ❯

Citations

Nov 7, 2015·Drug Metabolism Reviews·Jamie F LuMary Bebawy
Jun 24, 2015·Critical Reviews in Oncology/hematology·M P WeenC Ricciardelli
Jul 30, 2016·Scientific Reports·Nuzhat AhmedGeorge Kannourakis
May 18, 2017·Expert Opinion on Drug Metabolism & Toxicology·Ela CerovskaPavel Soucek
Jul 8, 2015·The Journal of Pharmacology and Experimental Therapeutics·Jiagen WenWei Zhang
Apr 12, 2020·International Journal of Cancer. Journal International Du Cancer·Moonsun JungMichelle J Henderson
Jun 11, 2016·Biochemical Society Transactions·David HardyAlice J Rothnie
Jul 5, 2017·Frontiers in Pharmacology·Tea Lanišnik RižnerCsilla Özvegy-Laczka
Dec 15, 2020·EMBO Molecular Medicine·Sophia CederKlas G Wiman
Sep 28, 2016·Molecular Cancer Therapeutics·Jerec W RicciRichard S Larson
Aug 2, 2019·The American Journal of Pathology·Ruxandra A NagyUwe J F Tietge
Jun 15, 2021·Pathology, Research and Practice·Han Wang, Yanxia Jiang

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.