Clinicopathological indicators of survival among patients with pulmonary carcinoid tumor

Acta Oncologica
Tiina VesterinenJohanna Arola

Abstract

Pulmonary carcinoids (PC) are rare malignant neoplasms that cover approximately 1% of all lung cancers. PCs are classified by histological criteria as either typical (TC) or atypical (AC). Histological subtype is the most studied prognostic factor. The aim of this study was to evaluate if other tissue or clinical features are associated with patient outcomes. We retrospectively reviewed clinical records of 133 PC patients who underwent operation in the Helsinki University Hospital between 1990 and 2013. Tissue specimens were re-evaluated, processed into tissue microarray format and stained immunohistochemically with serotonin, calcitonin, adrenocorticotropic hormone (ACTH), thyroid transcription factor-1 (TTF-1) and Ki-67. Survival and risk analyses were performed. Based on histology, 75% (n = 100) of the tumors were TCs and 25% (n = 33) ACs. TCs had higher 10-year disease-specific survival (DSS) rate than ACs (99% (95% CI, 93-100%) for TCs vs. 82% (95% CI, 61-92%) for ACs). Hormonally active tumors expressing serotonin, calcitonin or ACTH were noted in 53% of the specimens but hormonal expression was not associated with DSS. TTF-1 was positive in 78% of the specimens but was not associated with DSS. Ki-67 index varied between ...Continue Reading

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Citations

Jan 19, 2019·The Journal of Clinical Endocrinology and Metabolism·Tiina VesterinenCaj Haglund
Jul 3, 2019·Virchows Archiv : an International Journal of Pathology·Stefano La RosaAndrea Imperatori
May 21, 2020·Scandinavian Journal of Immunology·Branislava StankovicAlexandre Corthay
Feb 25, 2020·Acta Clinica Belgica·Othmane MohibDavid De Bels
Aug 7, 2019·Virchows Archiv : an International Journal of Pathology·Tiina VesterinenJohanna Arola
Mar 7, 2021·Revue des maladies respiratoires·H SneneB Louzir
Nov 7, 2021·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tiina VesterinenJohanna Arola

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