Clinicopathological Outcomes of Patients with Early Gastric Cancer after Non-Curative Endoscopic Submucosal Dissection

Digestion
Shu HoteyaMitsuru Kaise

Abstract

Endoscopic submucosal dissection (ESD) was developed to resect early gastric cancer (EGC), which could not be resected by conventional endoscopic mucosal resection, and the indications for ESD are expanding to include more types of EGCs. Favorable long-term outcomes of ESD for EGCs that meet the expanded curability criteria have been reported. However, the outcomes of non-curative ESD are not known in detail. We analyzed the outcomes of 165 EGCs in 165 patients after non-curative ESD, as well as the clinical course. Of these patients, 109 underwent additional surgical resection (group S) and 56 patients were followed up without additional surgery (group F). The complete resection rate was 90.7% (39/43) for intramucosal cancer (M), 97.3% (36/37) for minimally submucosal invasive cancer (SM1), and 74.1% (63/85) for deep submucosal invasive cancer (SM2). The lymph node metastasis rate was 0% for M, 5.4% for SM1, and 10.6% for SM2 cancers. Regarding long-term survival, although the number of patients who died of another disease was significantly higher in group F than in group S, there was no significant difference in overall survival between the groups. The resectability of ESD for ECGs with an invasion depth of M to SM1 after non...Continue Reading

Citations

Oct 11, 2016·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Haruhisa SuzukiHitoshi Katai
Apr 17, 2018·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Hirohito MoriTsutomu Masaki
Oct 7, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Waku HattaTooru Shimosegawa
May 10, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Keiichi FujiyaMasanori Terashima
Sep 19, 2019·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Waku HattaAtsushi Masamune
Nov 26, 2019·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Hiroki OsumiJunko Fujisaki
Jul 18, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hye Jin KangHyun Chae Jung
Aug 25, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hyo-Joon YangIl Ju Choi
Apr 21, 2017·Surgical Endoscopy·Hee Sung KimByung Sik Kim
Dec 19, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yosuke ToyaTakayuki Matsumoto
May 21, 2021·Chronic Diseases and Translational Medicine·Dong-Ya HuShu-Tian Zhang

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