Clinicopathological significance and prognostic value of leukemia-related protein 16 expression in invasive ductal breast carcinoma

Cancer Science
Po ZhaoWei Dong Han

Abstract

To explore the expression of leukemia-related protein 16 (LRP16) in invasive ductal breast carcinoma and analyze its correlation with clinicopathological feature and prognosis, immunohistochemistry was performed on 100 cases of invasive ductal breast carcinoma. Medical records were reviewed and clinicopathological analysis was performed. Leukemia-related protein 16 expression was detected in 33 of 100 cases (33%) of the invasive ductal breast carcinoma. Expression of LRP16 in carcinoma was obviously higher than that in normal breast tissue. LRP16 protein expression was found in 27.6% (21/76) of carcinoma at stage I and II, and 50.0% (12/24) of carcinoma at stage III and IV. LRP16 expression was found correlative with metastasis in the axillary lymph node (P = 0.001), stage (P = 0.042), estrogen receptor (ER) expression (P = 0.001), fragile histidine triad (FHIT) expression (P = 0.015) and CD133 expression (P = 0.038), but not with grade (P = 0.543), tumor size (P = 0.263), age (P = 0.840), menopause (P = 0.701) and HER-2 gene amplification (P = 0.463). The difference of the mean disease free survival (DFS) time between cancer patients with LRP16 expression (43.7 months) and those without (77.7 months) was statistically signific...Continue Reading

References

Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
Nov 19, 2004·Nature·Sheila K SinghPeter B Dirks
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexander PerathonerAlbert Amberger
Jul 7, 2005·Pathology International·Gulnur GulerKay Huebner
Jul 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Banu ArunRaheela Ashfaq
Jun 23, 2006·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Tomohiro Hamada, Yasuo Sakuma
Jun 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laurie Beth J MoralesRhonda R Voskuhl
Aug 25, 2006·Journal of Gastroenterology and Hepatology·Bo FengZheng-Gang Zhu
Nov 7, 2006·Molecular Immunology·Masafumi ZaitsuTerumi Midoro-Horiuti
Nov 24, 2006·Nature·Lucia Ricci-VitianiRuggero De Maria
Mar 6, 2007·The Laryngoscope·Liang ZhouJack J Jiang
Apr 11, 2007·Neuropharmacology·Marc MorissetteThérèse Di Paolo
May 23, 2007·Journal of Neuro-oncology·Rudolph J SchrotJames M Angelastro
Jan 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Felix ZeppernickChristel C Herold-Mende
Apr 12, 2008·World Journal of Pediatrics : WJP·Qiang-Song TongJia-Bin Cai
May 16, 2008·International Journal of Clinical Practice·W SongK Dou
Nov 21, 2008·American Journal of Clinical Pathology·John M S BartlettElizabeth A Mallon
Dec 18, 2008·Future Oncology·Flavia PichiorriCarlo M Croce
Dec 26, 2008·Journal of Experimental & Clinical Cancer Research : CR·Mingyu ZhangJiasheng Fang
Apr 17, 2009·Cancer Treatment Reviews·Jin-Xiang ChengXiang Zhang
May 1, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·David HorstThomas Kirchner
May 14, 2009·World Journal of Gastroenterology : WJG·Dongho ChoiSeung-Sam Paik
Jul 9, 2009·BMC Cancer·Gabriella FerrandinaGiovanni Scambia
Oct 14, 2009·World Journal of Gastroenterology : WJG·Ya-Zhuo LiWei-Dong Han
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giuseppe CuriglianoAron Goldhirsch
Apr 1, 2010·World Journal of Gastroenterology : WJG·Hong Qing XiWei Dong Han

❮ Previous
Next ❯

Citations

Jul 23, 2014·ACS Chemical Biology·Brett M HirschVern L Schramm
Feb 26, 2015·Journal of Cellular Physiology·Francesca BianchiManuela Campiglio
Sep 30, 2016·Seminars in Cell & Developmental Biology·Melanija Posavec MarjanovićIvan Ahel
Feb 8, 2018·Frontiers in Microbiology·Thomas AgnewIvan Ahel
Apr 18, 2019·Open Biology·Luca PalazzoIvan Ahel
Mar 17, 2019·Cellular Oncology (Dordrecht)·Ahmad GhasemiSeyed Isaac Hashemy
Apr 5, 2013·PloS One·Eva CubilloAmparo Cano
Apr 4, 2021·Cells·Ann-Katrin Hopp, Michael O Hottiger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.