Clinicopathological significance of cancer-associated fibroblasts in papillary thyroid carcinoma: a predictive marker of cervical lymph node metastasis

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Jae-Gu ChoJeong-Soo Woo

Abstract

Most tumors have obvious biologically active fibroblasts known variously as myofibroblasts or cancer-associated fibroblasts (CAFs) in the stroma. CAFs have been known as an important factor of cancer invasion and metastasis. This study aimed to investigate the presence of CAFs in patients with papillary thyroid carcinoma (PTC) and evaluate the correlation between CAFs and cervical lymph node (LN) metastasis in PTC through immunohistochemistry. The medical records of 128 patients who were diagnosed with PTC from January 1, 2010 to December 31, 2010 were reviewed, and 78 patients who underwent total thyroidectomy with or without neck dissection, were included in this study. A retrospective pathological evaluation was performed to verify the presence of CAFs. CD34 and α-smooth muscle actin (SMA) were used as markers of CAFs. Among 78 patients with PTC, 65 had desmoplastic stromal reaction around the PTC. Through immunohistochemical study of anti-CD34 and α-SMA antibodies, CAFs were found in 42 (64.6%) cases with desmoplastic stroma around the PTC. Univariate analysis showed that tumor size and CAFs were the risk factors of LN metastasis in patients with PTC, while multivariate analysis revealed that CAFs were the only independent ...Continue Reading

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Citations

Sep 11, 2019·International Journal of Molecular Sciences·Silvia Martina FerrariAlessandro Antonelli
Nov 25, 2019·Thoracic Cancer·Arik Bernard SchulzeGeorg Evers
Dec 4, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jianzhong HouBo Wu
Apr 16, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David SusterSaul Suster
Nov 10, 2020·Endocrinology and Metabolism·Laura Fozzatti, Sheue-Yann Cheng
Mar 7, 2021·International Journal of Molecular Sciences·Jinwei HuXiangpeng Yuan
Oct 14, 2021·Thyroid : Official Journal of the American Thyroid Association·Sanjana BallalChandrasekhar Bal

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