Clinicopathological significance of caspase-8 and caspase-10 expression in rectal cancer

Oncology
Bing XuXiao-Feng Sun

Abstract

To investigate the expression of caspase-8 and -10 in rectal adenoma, adenocarcinoma and the corresponding normal mucosa tissue, and to clarify the relationship between their expression and clinicopathological parameters of rectal cancer. The expression of caspase-8 and -10 was determined by real-time RT-PCR and immunohistochemistry in 36 rectal adenomas, 93 rectal cancers and 93 corresponding normal rectal mucosa samples. Compared with normal mucosa, the mRNA expression of caspase-8 was higher in adenomas (p = 0.003), while that of caspase-10 was lower in adenomas (p = 0.035) and cancers (p = 0.001). Immunohistochemical results showed caspase-8 up-regulation in adenomas (p = 0.014), and caspase-10 down-regulation in adenomas (p = 0.034) and cancers (p < 0.001) compared with normal mucosa samples. Cancers with poor differentiation had lower caspase-10 mRNA and protein levels than those with better differentiation (p = 0.041 and p = 0.046, respectively). The protein expression of caspase-8 and -10 was in accordance with the mRNA expression (p = 0.043 and p = 0.018, respectively). Caspase-8 expression was up-regulated in rectal adenomas. Caspase-10 expression was down-regulated in both rectal adenomas and cancers, and was further...Continue Reading

Citations

May 12, 2011·International Journal of Colorectal Disease·Xiao-Gang ShenXiao-Feng Sun
Jul 17, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·X-G ShenX-F Sun
Jun 24, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Donal P McLornanPatrick G Johnston
Dec 29, 2010·PLoS Genetics·Luis B BarreiroYoav Gilad
Apr 21, 2018·Indian Journal of Pathology & Microbiology·Nilay Şen TürkLevent Tuncay
Aug 10, 2021·Frontiers in Oncology·Weili MinYang Zhao

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