Clinicopathological significance of GADD45 gene alterations in human familial breast carcinoma

Breast Cancer Research and Treatment
Elisa SensiMaria A Caligo

Abstract

GADD45 is a DNA damage responsive gene, induced following BRCA1 expression. Mutations at GADD45 might substitute for p53 alterations in hereditary breast tumours characterized by wild-type p53. We analyzed GADD45 alterations in 59 (15 BRCA-associated) familial breast carcinomas. No mutations were found. LOH at GADD45 locus was identified in 19/59 tumours. GADD45 does not appear to be a frequent mutational target in hereditary breast cancer.

References

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Apr 1, 1996·Human Genetics·H BlaszykJ S Kovach
May 25, 1999·Genes, Chromosomes & Cancer·S J RamusL S Friedman
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Nov 4, 2000·Cell Proliferation·P Campomenosi, P A Hall
Aug 27, 2002·Nature Genetics·Anne-Renee Hartman, James M Ford
Dec 16, 2003·Breast Cancer Research and Treatment·Elisa SensiMaria A Caligo

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Citations

Mar 20, 2008·Journal of Human Genetics·Sylvie DesjardinsFrancine Durocher
Dec 15, 2010·Journal of Biomolecular Structure & Dynamics·T F Solov'evaM P Isaeva
Apr 28, 2005·Cancer Control : Journal of the Moffitt Cancer Center·Vesna DapicAlvaro N A Monteiro

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