Clinicopathological Significance of Large Tumor Suppressor (LATS) Expression in Gastric Cancer

Journal of Gastric Cancer
Myoung Won SonMoon Soo Lee

Abstract

The aims of this study were to evaluate the expression of the large tumor suppressor (LATS) genes LATS1 and LATS2 by immunohistochemical staining of gastric cancer, and to evaluate the clinicopathological significance of LATS expression and its correlation with overall survival (OS). LATS1 and LATS2 expression in a tissue microarray was detected by immunohistochemistry, using 264 gastric cancer specimens surgically resected between July 2006 and December 2009. Low expression of LATS1 was significantly associated with more advanced American Joint Committee on Cancer (AJCC) stage (P=0.001) and T stage (P=0.032), lymph node (LN) metastasis (P=0.040), perineural invasion (P=0.042), poor histologic grade (P=0.007), and diffuse-type histology by the Lauren classification (P=0.033). Low expression of LATS2 was significantly correlated with older age (≥65, P=0.027), more advanced AJCC stage (P=0.001) and T stage (P=0.001), LN metastasis (P=0.004), perineural invasion (P=0.004), poor histologic grade (P<0.001), and diffuse-type histology by the Lauren classification (P<0.001). Kaplan-Meier survival analysis revealed significantly poor OS rates in the groups with low LATS1 (P=0.037) and LATS2 (P=0.037) expression. Expression of LATS1 or ...Continue Reading

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Citations

Oct 6, 2019·Journal of Cancer Research and Clinical Oncology·Céline MontavonAndré Fedier
May 20, 2020·Seminars in Cancer Biology·Milad MoloudizargariSeyed Mohammad Nabavi
Nov 6, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ali Akbar SamadaniAhmad Reza Bandegi
Sep 8, 2021·The Prostate·Tsuyoshi MatsudaHideki Sakai

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Methods Mentioned

BETA
surgical
dissection
surgical resection
Chips

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )

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