Clinicopathological significance of major histocompatibility complex class I-related chain a and B expression in thyroid cancer

The Journal of Clinical Endocrinology and Metabolism
Xiulong XuRichard A Prinz

Abstract

Major histocompatibility complex class I-related chains A and B (MICA/B) are two stress-inducible ligands for the immunoreceptor NKG2D that is expressed on cytotoxic T cells and natural killer (NK) cells. It is not known whether MICA/B expression is up-regulated in thyroid cancer as a result of oncogene activation. The objective of the investigation was to study MICA/B expression and regulation in thyroid cancer and its role in mediating the cytotoxicity of NK cells. MICA/B expression in thyroid cancer was analyzed by immunohistochemical staining. Cell surface MICA/B levels in thyroid tumor cell lines and fresh tumor cells were analyzed by flow cytometric analysis. The susceptibility of thyroid tumor cells to NK cell killing was tested by using (51)Cr release assay. MICA/B was expressed at moderate or high levels in 18 of 39 papillary thyroid carcinomas and four of eight anaplastic thyroid carcinomas. MICA/B expression was confirmed by flow cytometric analysis in three fresh thyroid neoplasms. MICA/B expression was detected in eight of 10 thyroid tumor cell lines and correlated with their sensitivity to killing by the NKG2/D-positive NK-92 cells. Blocking of NKG2D and MICA/B interaction by specific antibodies partially led to t...Continue Reading

Citations

Feb 6, 2013·Human Immunology·FengHua PanWei Tian
Jan 16, 2013·Thyroid : Official Journal of the American Thyroid Association·Jena D French
Apr 29, 2008·International Immunology·Béatrice Le Maux ChansacFathia Mami-Chouaib
Feb 17, 2009·Expert Opinion on Biological Therapy·Michael A MorseJanet M D Plate
Dec 28, 2007·The Journal of Investigative Dermatology·Taisuke ItoRalf Paus
Jul 2, 2009·International Journal of Cancer. Journal International Du Cancer·Christine SersReinhold Schäfer
Jun 9, 2007·European Journal of Immunology·Sandra Rodríguez-RoderoCarlos López-Larrea
Apr 2, 2014·Tissue Antigens·F PanW Tian
Oct 25, 2016·The Lancet. Diabetes & Endocrinology·Jena D FrenchMabel Ryder
Oct 25, 2007·International Journal of Cancer. Journal International Du Cancer·Young Suk JoMinho Shong
Feb 20, 2018·Molecular Cancer·George E NaoumWaleed Arafat
Aug 27, 2016·Oncotarget·Claudia ManziniGabriella Pietra
Nov 1, 2013·International Journal of Oncology·Zilvinas DambrauskasBritt-Marie Iresjö
Aug 16, 2019·International Journal of Molecular Sciences·Gilda VarricchiMaria Rosaria Galdiero
Nov 17, 2020·Frontiers in Endocrinology·Zhenyu XieJian Zhang
Apr 21, 2019·Experimental and Molecular Pathology·Marcelo J SakiyamaChristian R Gomez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.