Clinicopathological significance of p14(ARF) expression in lung cancer: a meta-analysis

OncoTargets and Therapy
Fang WangSheng Ye

Abstract

p14(ARF), a tumor suppressor protein, encoded by the p16 tumor suppressor gene, has been reported to be associated with the clinicopathological features of lung cancer. However, the evaluated outcomes were inconsistent and remained inconclusive. In this study, we conducted a meta-analysis to clarify the significance of p14(ARF) expression in lung cancer pathogenesis. Electronic databases, PubMed, Web of Knowledge, Embase, and CNKI, were retrieved to collect relevant articles with inclusion and exclusion criteria. Using Stata 12.0 software, 95% confidence intervals (CIs) and odds ratios (ORs) were calculated. A total of 15 eligible case-control studies that evaluated the relationship between p14(ARF) expression and lung cancer were included in the meta-analysis. The results demonstrated that there were significant associations between p14(ARF) expression and the risk of non-small-cell lung cancer (NSCLC), lung adenocarcinoma, and lung squamous carcinoma (for NSCLC, OR =11.02, 95% CI =5.30-22.92; for lung adenocarcinoma, OR =7.28, 95% CI =3.92-13.50; and for lung squamous carcinoma, OR =14.40, 95% CI =2.83-73.24). In the stratified analysis based on race, significant associations between p14(ARF) expression and lung cancer risk w...Continue Reading

Citations

Jun 14, 2019·Frontiers in Oncology·Sandra CamargoEduardo Mitrani
Jan 5, 2021·Molecular and Cellular Biochemistry·Ruju Vashi, Bhoomika M Patel
Jan 16, 2021·Biomolecules·Nefeli LagopatiVassilis Gorgoulis

❮ Previous
Next ❯

Software Mentioned

Stata

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.