Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis

International Journal of Surgery
Guo ZuNingwei Che

Abstract

The relationship between SIRT1 and clinicopathological parameters of colorectal cancer (CRC) is controversial. To evaluate the clinicopathological and prognostic value of silent mating type information regulation 2 homolog-1 (SIRT1) expressions in patients with CRC, a meta-analysis was performed. We conducted a meta-analysis to investigate the impact of SIRT1 on clinicopathological parameters and prognosis in CRC patients. Studies assessing the relationship between these parameters and SIRT1 expression in CRC were identified up to September, 2015. Seven studies met the inclusion criteria. Our results showed that SIRT1 expression was correlated with depth of invasion (OR = 0.922, 95% CI: 0.646-1.316, P = 0.005), lymph node metastasis (OR = 1.001, 95% CI: 0.781-1.283, P = 0.000) and TNM stage (OR = 1.103, 95% CI: 0.892-1.365, P = 0.008). Furthermore, we found that SIRT1 expression predicted a poor overall survival (OS) in CRC patients (OR = 1.220, 95% CI: 0.955-1.558, P = 0.037, fixed-effect). The overall data of the present meta-analysis showed that SIRT1 expression was not correlated with clinicopathological features except for depth of invasion, lymph node metastasis and TNM stage. Simultaneously, SIRT1 overexpression predicte...Continue Reading

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Citations

Jan 6, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G ZuX Zhang
Dec 19, 2017·Oncology Letters·Magdalena SzaryńskaZbigniew Kmieć
Jan 8, 2020·Nutrients·Maria CastejónAlberto Diaz-Ruiz
Sep 12, 2018·Apoptosis : an International Journal on Programmed Cell Death·Debashri MannaRita Ghosh
Feb 11, 2021·Personalized Medicine·Alicja ZalewskiScott A Waldman
Jul 2, 2020·The Korean Journal of Internal Medicine·Guk Jin LeeIn Sook Woo

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