Clinicopathological study of invasive extramammary Paget's disease: subgroup comparison according to invasion depth

Journal of the European Academy of Dermatology and Venereology : JEADV
T ShiomiK Ohara

Abstract

Extramammary Paget's disease (EMPD) is a distinct form of malignant skin neoplasm. Invasive EMPD is relatively rare and its detailed histopathological features have not been investigated to date. Surgical specimens were obtained from 51 patients with primary invasive EMPD. Clinical data including lymph node status were retrieved from the patients' medical records. Cases were divided into subgroups according to invasion depth: dermal invasion ≤ 1 mm (minimal invasion) and dermal invasion > 1 mm in depth. Histological patterns (nodular/glandular pattern or micronodular pattern), lymphatic/venous invasion, mitosis and lymph node status were compared between the two groups. The invasive EMPDs included 26 cases (51.0%) with dermal invasion ≤ 1 mm (minimal invasion) and 25 cases (49.0%) with dermal invasion > 1 mm in depth. Lymph node metastasis was detected in 2/26 (7.7%) patients with minimally invasive EMPD. Nodular/glandular pattern (72.0%), lymphatic/venous invasion (52.0%), mitosis (88.0%) and nodal metastasis (88.0%) were all significantly more frequent in cases with dermal invasion > 1 mm, compared to EMPDs with dermal invasion ≤ 1 mm (minimal invasion) (P < 0.001). These results suggest that invasive EMPD can be divided acco...Continue Reading

References

Jul 1, 1990·Gynecologic Oncology·G A FeuerA Calanog
Mar 24, 2000·The British Journal of Dermatology·T Ohnishi, S Watanabe
Nov 7, 2000·Journal of Clinical Pathology·J Lloyd, A M Flanagan
Jul 30, 2002·Gynecologic Oncology·P E EllisC W Perrett
Dec 8, 2004·Gynecologic Oncology·Thomas EwingGregory J Rumore
Feb 6, 2008·Journal of Dermatological Science·Satoru AoyagiHiroshi Shimizu
Dec 3, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Ruthy Shaco-LevyStanley J Robboy

❮ Previous
Next ❯

Citations

Apr 23, 2013·Clinical & Developmental Immunology·Taku FujimuraSetsuya Aiba
Aug 21, 2014·The British Journal of Dermatology·M HataT Inoue
Mar 27, 2018·Expert Review of Anticancer Therapy·Takamichi ItoMasutaka Furue
Dec 18, 2014·Clinical Obstetrics and Gynecology·David CarrShannon Trotter
May 15, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·M HataT Inoue
Mar 6, 2018·Frontiers in Oncology·Keitaro Fukuda, Takeru Funakoshi
Apr 30, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Mingquan ChenDongjie Li
May 5, 2018·Current Treatment Options in Oncology·Uwe WollinaSven Petersen
Jan 6, 2015·The Journal of Dermatology·Takamichi ItoHiroshi Uchi
May 25, 2016·BJR Case Reports·Andres VasquezMariam Rolon
Apr 9, 2015·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Shiho AsakaHiroyoshi Ota
Apr 16, 2021·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Yuan-Yuan MaLe-Hang Guo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Dermatology
Seok-Jong LeeKorean Society for Skin Cancer and Korean Dermatopathology Research Group
Annals of Oncology : Official Journal of the European Society for Medical Oncology
Masaharu HataTomio Inoue
Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Alexandra BoehringerHelmut Breuninger
© 2022 Meta ULC. All rights reserved