PMID: 8963024Sep 1, 1995Paper

Clinicopathological study of minimum-sized hepatocellular carcinoma: an approach to the definition of early hepatocellular carcinoma

Journal of Gastroenterology and Hepatology
S R KimH Itoh

Abstract

Clinicopathologic examination of 33 nodules from 23 cases of minimum-sized hepatocellular carcinoma (HCC), less than 15 mm in diameter, was carried out by imaging and clinical follow up. On ultrasound (US), 16 hypoechoic nodules (48%) and 15 hyperechoic nodules (45%) on angiography 7 tumour stains (21%) and on computerized tomography (CT) 3 low density nodules (9%) were detected. Of 27 nodules on lipiodol CT (LpCT), 7 lipiodol-deposited nodules (26%) were detected. Of 16 nodules on CO2US angiography (US-angiography), 7 hypervascular (44%), 5 hypovascular (31%) and 4 isovascular nodules (25%) were detected. Of 13 nodules on CT during arterial portography (CTAP), 7 perfusion defect nodules (54%) were detected. The nodules were graded according to the Edmondson & Steiner Classification. Three nodules were resected; grossly, two were not distinct and one was poorly demarcated. Histologically, they were highly differentiated with irregularly-thin trabecular-patterned HCC where portal triads were detected. Cancer cells invaded the non-cancerous liver cells by replacement, and the border between the cancerous and non-cancerous regions was unclear; the latter region manifested chronic hepatitis or liver cirrhosis without hyperplasia. M...Continue Reading

References

Jul 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Okuda
Mar 1, 1988·Annals of Internal Medicine·A M Di BisceglieM T Lotze
May 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F KondoK Okuda
Sep 1, 1986·AJR. American Journal of Roentgenology·K TakayasuN Okazaki
Aug 1, 1986·Seminars in Liver Disease·T Nakashima, M Kojiro
Nov 1, 1986·Journal of Computer Assisted Tomography·Y ItaiN Yashiro
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·F KondoY Kondo
Jul 1, 1987·Radiology·K ItohK Mori
Apr 1, 1980·Radiology·T W BroderickJ Wilcox
Apr 1, 1981·The British Journal of Radiology·P A DubbinsW M Melia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.