Clinicopathological study on TTV infection in hepatitis of unknown etiology

World Journal of Gastroenterology : WJG
Zhong-Jie HuZhao-Xia Luo

Abstract

To investigate the state of infection, replication site, pathogenicity and clinical significance of transfusion transmitted virus (TTV) in patients with hepatitis, especially in patients of unknown etiology. Liver tissues taken from 136 cases of non-A non-G hepatitis were tested for TT virus antigen and nucleic acid by in situ hybridization (ISH) and nested-polymerase chain reaction (PCR). Among them, TT virus genome and its complemental strand were also detected in 24 cases of autopsy liver and extrahepatic tissues with ISH. Meanwhile, TTV DNA was detected in the sera of 187 hepatitis patients by nested-PCR. The pathological and clinical data of the cases infected with TTV only were analyzed. In liver, the total positive rate of TTV DNA was 32.4% and the positive signals were located in the nuclei of hepatocytes. In serus, TTV DNA was detected in 21.4% cases of hepatitis A-G, 34.4% of non-A non-G hepatitis and 15% of healthy donors. The correspondence rate of TTV DNA detection between liver tissue with ISH and sera with PCR was 63.2% and 89.3% in the same liver tissues by ISH and by PCR, respectively. Using double-strand probes and single-strand probes designed to detect TTV genome, the correspondence rate of TTV DNA detected ...Continue Reading

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Citations

Oct 16, 2002·World Journal of Gastroenterology : WJG·Jie YanXiao-Zhi Zhong
Jun 15, 2011·Virologica Sinica·Zheng Hou, Gengfu Xiao
Feb 15, 2015·Archives of Virology·Sonia SpandoleGrigore Mihăescu
Oct 28, 2015·Hepatitis Monthly·Mohammad Javad KazemiJavad Moayedi
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May 1, 2020·World Journal of Gastroenterology : WJG·Vasiliy I ReshetnyakTatiana I Karlovich
Sep 19, 2008·Virology·Bettina MuellerAnnette Mankertz

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